H. Elsohly

Publications115
h-index32
Citations3,186
Highly Influential Citations111
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Localization of Artemisinin and Artemisitene in Foliar Tissues of Glanded and Glandless Biotypes of Artemisia annua L.
TLDR
The tissue localization of the antimalarial sesquiterpenoid compound artemisinin in annual wormwood (Artemisia annua L.) was determined by differential extraction of a glanded biotype and through the use of a glandsless biotype, indicating that artemisine and artemisitene present in foliar tissue are localized entirely in the subcuticular space of capitate glands of A. annua.
Artemisinin, a Constituent of Annual Wormwood (Artemisia annua), is a Selective Phytotoxin
Artemisinin (qinghaosu), a sesquiterpenoid lactone peroxide constituent of annual wormwood ( Artemisia annua L. # ARTAN) that is used as an antimalarial drug, was tested for phytotoxic properties. It…
Natural products inhibiting Candida albicans secreted aspartic proteases from Lycopodium cernuum.
Activity-guided fractionation of an ethanol extract of Lycopodium cernuum for Candida albicans secreted aspartic proteases (SAP) inhibition resulted in the identification of six new (1-6) and four…
Microbial metabolism studies of the antimalarial sesquiterpene artemisinin.
TLDR
Scale-up fermentation with Nocardia corallina and Penicillium chrysogenum has resulted in the production of two major microbial metabolites that have been characterized with the use of 2D-nmr techniques and have been identified as deoxyartemisinin and 3 alpha-hydroxydeoxyart Artemisinin.
Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis, aphanizomenon flos-aquae and Chlorella pyrenoidosa.
TLDR
Three new high molecular weight polysaccharide preparations isolated from food-grade microalgae that are potent activators of human monocytes/macrophages are identified: "Immulina" from Spirulina platensis, "Immunon" from Aphanizomenon flos-aquae, and "Immurella" from Chlorella pyrenoidosa.
Constituents of Nelumbo nucifera leaves and their antimalarial and antifungal activity.
Fatty acid synthase inhibitors from plants: isolation, structure elucidation, and SAR studies.
TLDR
Three'-Formylgenistein and ellagic acid 4-O-alpha-l-rhamnopyranoside were the most potent compounds against FAS, with IC(50) values of 2.3 and 7.5 microg/mL, respectively.
Flavanone glycosides from Miconia trailii.
TLDR
Assay-guided fractionation of the ethanol extract of the twigs and leaves of Miconia trailii yielded two new flavanone glycosides, matteucinol and farrerol, and the structures of 1-8 were elucidated by spectroscopic methods, including 2D NMR.
Absolute configuration, conformation, and chiral properties of flavanone-(3→8″)-flavone biflavonoids from Rheedia acuminata
Phenolic compounds from Nymphaea odorata.
Assay-guided fractionation of the ethanol extract of Nymphaea odorata resulted in the identification of two lignans, one new (1) and one known (2), together with six known flavonol glycosides (3-8).…
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