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Hepatocellular carcinoma: epidemiology and molecular carcinogenesis.
A detailed understanding of epidemiologic factors and molecular mechanisms associated with HCC ultimately could improve current concepts for screening and treatment of this disease.
Epidemiology of viral hepatitis and hepatocellular carcinoma.
- H. El‐Serag
- Medicine, BiologyGastroenterology
- 1 May 2012
This review summarizes the risk factors for HCC among HBV- or HCV-infected individuals, based on findings from epidemiologic studies and meta-analyses, as well as determinants of patient outcome and the HCC disease burden, globally and in the United States.
Rising incidence of hepatocellular carcinoma in the United States.
The incidence of hepatocellular carcinoma increased significantly among younger persons (40 to 60 years old) during the period from 1991 to 1995 as compared with earlier periods, and the age-specific incidence of this cancer has progressively shifted toward younger people.
- H. El‐Serag
- Medicine, BiologyThe New England journal of medicine
The greatest proportional increase in cases of hepatocellular carcinoma has been seen among Hispanics and whites between 45 and 60 years of age, and the highest incidence rates reported in regions where infection with hepatitis B virus is endemic: Southeast Asia and sub-Saharan Africa.
Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review
GERD is prevalent worldwide, and disease burden may be increasing, and prevalence estimates show considerable geographic variation, but only East Asia shows estimates consistently lower than 10%.
The epidemiology of cholangiocarcinoma.
Some data point to a potential role for chronic liver disease, hepatitis C, and probably hepatitis B infections in the development of ICC, as well as the recent increasing trends of ICC in the United States.
Epidemiology of gastro-oesophageal reflux disease: a systematic review
The prevalence and incidence of gastro-oesophageal reflux disease was estimated from 15 studies which defined GORD as at least weekly heartburn and/or acid regurgitation and met criteria concerning sample size, response rate, and recall period.
Risk factors for cholangiocarcinoma
The consistent use of a more refined classification would allow a better understanding of risk factors for CC, and some potential risk factors seem to have a differential effect on CC, depending on the site.
Diagnosis and treatment of hepatocellular carcinoma.
A summary of the most recent information on screening, diagnosis, staging, and different treatment modalities of HCC, as well as the recommended management approach is presented.
Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma.
Among men with diabetes, the risk of chronic nonalcoholic liver disease and hepatocellular carcinoma is doubled, independent of alcoholic liver disease, viral hepatitis, or demographic features.