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Pharmacokinetics of pyrazinamide and its metabolites in healthy subjects
- C. Lacroix, T. Phan Hoang, O. Lafont
- Biology, ChemistryEuropean Journal of Clinical Pharmacology
The plasma and urine pharmacokinetic parameters of pyrazinamide and of its metabolites have been studied and the activity of a microsomal deamidase was found to be the limiting factor.
Interaction between allopurinol and pyrazinamide.
- C. Lacroix, C. Guyonnaud, M. Chaou, H. Duwoos, O. Lafont
- Medicine, BiologyThe European respiratory journal
- 1 October 1988
Analysis of the pharmacokinetic parameters showed that Al induced marked changes in levels of PZA metabolites and accumulation of pyrazinoic acid, which is directly responsible for the inhibition of renal urate secretion, so other drugs, which do not involve xanthine oxidase inhibition, should be used in the treatment of this side effect of chemotherapy.
Three-month follow-up of arterial blood gas determinations in candidates for long-term oxygen therapy. A multicentric study.
- P. Lévi-Valensi, E. Weitzenblum, J. Pedinielli, J. Racineux, H. Duwoos
- MedicineThe American review of respiratory disease
- 1 April 1986
One hundred seventeen patients with severe chronic obstructive pulmonary disease whose PaO2 in a stable clinical state ranged from 41 to 59 mmHg, were included in a multicentric controlled study on…
Haemodialysis of pyrazinamide in uraemic patients
The high dialysability shows that PZA can property be administered at the end of each dialysis session in the usual dose of 25 to 30 mg·kg−1.
Pharmacokinetics of pyrazinamide and its metabolites in patients with hepatic cirrhotic insufficiency.
- C. Lacroix, J. Tranvouez, T. Phan Hoang, H. Duwoos, O. Lafont
- Medicine, BiologyArzneimittel-Forschung
The pharmacokinetics of pyrazinamide (Pirilène) and its metabolites are evaluated in ten subjects with hepatic insufficiency, after an oral dose of 19.3 +/- 0.6 mg.kg-1 and the results are compared…
[Treatment of severe chronic respiratory insufficiency patients with respirators at home. Indications and conditions of efficiency].
Simultaneous quantification of zidovudine and its metabolites in serum and urine by high-performance liquid chromatography using a column-switching technique.
[Theophylline-caffeine interaction in bronchial disease patients with cardiac and hepatic failure].
[Reversible hyperlactatemia induced by phenformin with muscular asthenia and cardio-respiratory signs].
[Muscular syndrome after exertion revealing the onset of endo- genous lactic acid intoxication following the administration of phenformin].