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A molecular phylogeny of the wild onions (Allium; Alliaceae) with a focus on the western North American center of diversity.
TLDR
The molecular phylogeny strongly supports previous morphology-based taxonomic groupings and suggests serpentine adaptation appears to have occurred multiple times within section Lophioprason, while the ancestor of the Californian center of diversity may not have been serpentine-adapted. Expand
Origin of Hawaiian Polystichum (Dryopteridaceae) in the context of a world phylogeny.
TLDR
The origin of the Hawaiian species of Polystichum is the result of multiple migrations to the islands, rather than single migrations yielding nearly all the local diversity as in the angiosperms, which provides a modern test of the premise that propagule vagility has a central role in determining pattern of evolution. Expand
miR-125a regulates cell cycle, proliferation, and apoptosis by targeting the ErbB pathway in acute myeloid leukemia.
TLDR
Analysis of microRNA profiling of acute myeloid leukemia patient samples revealed the ErbB pathway as significantly decreased with ectopic miR-125a, revealing Erb B inhibitors as potential novel therapeutic agents for treating miR -125a-low AML. Expand
Metagenomic analysis of an ecological wastewater treatment plant’s microbial communities and their potential to metabolize pharmaceuticals
TLDR
To determine whether the removal of micropollutants in ecological wastewater treatment plants (WWTPs) is promoted by the plant-microbe interactions, biofilm microbial communities growing on the surfaces of plant roots were profiled and compared to the microbial communities residing in the wastewater. Expand
Pumilio-2 Regulates Translation of Nav1.6 to Mediate Homeostasis of Membrane Excitability
TLDR
It is reported that Pum2 is indeed central to the homeostatic mechanism regulating membrane excitability in rat visual cortical pyramidal neurons and shows that loss of Pum 2 leads to increased sodium current (INa) and action potential firing, mimicking the response by these neurons to being deprived of synaptic depolarization. Expand
Matrix metalloproteinase-2 is downregulated in sciatic nerve by streptozotocin induced diabetes and/or treatment with minocycline: Implications for nerve regeneration
TLDR
It is suggested that MMP-2 downregulation may contribute to the regenerative deficits in diabetes and caution should be exhibited with its use as the balance between beneficial and detrimental outcomes may be critical in assessing the benefits of using minocycline to treat diabetic neuropathy. Expand
Spiraling into History: A Molecular Phylogeny and Investigation of Biogeographic Origins and Floral Evolution for the Genus Costus
TLDR
The ancestral reconstruction of pollination syndrome presents the first evidence in this genus of an evolutionary toggle in pollination morphologies, demonstrating both the multiple independent evolutions of ornithophily (bird pollination) as well as reversals to melittophilous (bee pollination). Expand
The phylogeny of Heliconia (Heliconiaceae) and the evolution of floral presentation.
TLDR
A dated phylogenetic framework is used to evaluate the evolution of two components of flower orientation that are hypothesized to be important for modulating pollinator discrimination and pollen placement and suggests that the most recent common ancestor of all extant Heliconia had resupinate flowers and erect inflorescences. Expand
Virus-induced gene silencing in the culinary ginger (Zingiber officinale): an effective mechanism for down-regulating gene expression in tropical monocots.
TLDR
It is demonstrated that barley stripe mosaic virus (BSMV) can infect two species within the Zingiberaceae, and that BSMV-VIGS can be applied to specifically down-regulate phytoene desaturase in the culinary ginger Zediber officinale, suggesting that extension of VIGS to monocots other than cereals has the potential for directed genetic analyses of many important temperate and tropical crop species. Expand
Triacetin‐based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma
TLDR
Given that GTA has been chronically administered safely to infants with Canavan disease, a leukodystrophy due to ASPA mutation, GTA‐mediated acetate supplementation may provide a novel, safe chemotherapeutic adjuvant to reduce the growth of glioma tumors. Expand
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