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Subclinical Hypothyroidism Is an Independent Risk Factor for Atherosclerosis and Myocardial Infarction in Elderly Women: The Rotterdam Study
This population-based study examined whether subclinical hypothyroidism and thyroid autoimmunity are associated with aortic atherosclerosis and myocardial infarction in elderly women who were participating in the Rotterdam Study. Expand
Premature ovarian failure and ovarian autoimmunity.
It is concluded in this review that POF in association with adrenal autoimmunity and/or Addison's disease (2-10% of the idiopathic POF patients) is indeed an autoimmune disease. Expand
Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy
Maternal thyroid function during early pregnancy is an important determinant of early fetal brain development because the fetal thyroid is unable to produce any T4 before 12–14 weeks' gestation.Expand
A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes.
The monocytes of a large proportion of bipolar patients and offspring of bipolar parents showed an inflammatory gene expression signature that opens new avenues for biomarker development with possibilities for disease prediction in individuals genetically at risk and for the subclassification ofipolar patients who could possibly benefit from anti-inflammatory treatment. Expand
The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes
A key role for mononuclear phagocytes in the pathogenesis of major psychiatric disorders is described and it is shown that microglia activation impacts neuronal development and function in brain areas congruent with the altered depressive and schizophrenia‐like behaviors. Expand
The mononuclear phagocyte system and its cytokine inflammatory networks in schizophrenia and bipolar disorder
There is evidence that the IL-2 system is activated in patients with schizophrenia (and perhaps those with mania), although independently of the activation of theIL-1, IL-6 and TNF systems, suggesting separate inducing mechanisms for monocyte and T-cell activation. Expand
High rate of autoimmune thyroiditis in bipolar disorder: lack of association with lithium exposure
Thyroid autoimmunity was highly prevalent in this sample of outpatients with bipolar disorder and not associated with lithium treatment, and these variables appear to be independent risk factors for the development of hypothyroidism, especially in women withipolar disorder. Expand
Postpartum thyroiditis and autoimmune thyroiditis in women of childbearing age: recent insights and consequences for antenatal and postnatal care.
Evidence is emerging that as women age subclinical hypothyroidism-as a sequel of postpartum thyroiditis-predisposes them to cardiovascular disease, no longer considered a mild and transient disorder. Expand
Immunohistochemical Characterization of Monocytes-Macrophages and Dendritic Cells Involved in the Initiation of the Insulitis and β-Cell Destruction in NOD Mice
The findings suggest that BM8+ macrophage infiltration into the female islets is linked to a β- cell destructive process, either as a destructive type of infiltration or as an infiltration meant to remove the β-cell debris caused by another immune assault. Expand
A high prevalence of organ-specific autoimmunity in patients with bipolar disorder
Bipolar disorder is associated with organ-specific autoimmunity to the antigens TPO, H/K ATPase, and GAD65, and the presence of Gad65A tended to be associated with the activity of bipolar disorder. Expand