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Changes in the Wnt signalling pathway in gastrointestinal cancers and their prognostic significance.
Many steps in the Wnt signalling pathway may be altered during the process of carcinogenesis. This Review focuses on the changes observed in gastrointestinal cancers. A literature search wasExpand
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Molecular prognostic markers in resectable colorectal liver metastases: a systematic review.
BACKGROUND Determination of prognosis in patients with resectable colorectal liver metastases (CLM) is desirable in order to improve case selection for surgery and tailor adjuvant treatment accordingExpand
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Expression of nuclear notch3 in pancreatic adenocarcinomas is associated with adverse clinical features, and correlates with the expression of STAT3 and phosphorylated Akt
Reactivation of the Notch signalling pathway occurs in a range of human malignancies. Previous research suggests that Notch3 is expressed in pancreatic adenocarcinomas, but neither cellular locationExpand
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HYPOXIA AND ANGIOGENESIS IN PANCREATIC CANCER
Background:  Pancreatic cancer remains one of the most lethal of all solid tumours of the gastrointestinal tract. It is characterized by late diagnosis, aggressive local invasion, early metastasisExpand
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Assessment of pancreatic malignancy with laparoscopy and intraoperative ultrasound
BackgroundStaging laparoscopy for pancreatic malignancy is controversial. This study aimed to assess the efficacy of laparoscopy with intraoperative ultrasound in the management of patients withExpand
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Frozen Section Diagnosis of Pancreatic Malignancy: A Sensitive Diagnostic Technique
Background: Patients with potentially resectable pancreatic masses, without evidence of metastatic disease, require surgical exploration. We assessed the reliability of frozen section diagnosis ofExpand
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Delayed presentation of life-threatening perineal sepsis following stapled haemorrhoidectomy: a case report.
Fournier's gangrene has been described after injection sclerotherapy and banding of haemorrhoids as well as after conventional haemorrhoidectomy. In addition, there have been several cases followingExpand
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Surgical bypass vs. endoscopic stenting for pancreatic ductal adenocarcinoma.
BACKGROUND The majority of patients with pancreatic cancer are non-resectable and jaundiced at presentation. Methods of palliation in such patients with locally advanced disease comprise endoscopicExpand
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Chemoprevention of Pancreatic Cancer: A Review of the Molecular Pathways Involved, and Evidence for the Potential for Chemoprevention
Background: Pancreatic cancer has a poor prognosis. The use of drugs or natural agents which inhibit or slow down tumour growth therefore has important potential in the development of futureExpand
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Basic principles of the molecular biology of cancer I
Abstract Although many different types of cancer exist, similar mechanisms may underlie their development. Cancers occur when cells escape the mechanisms that control cell growth, and proliferate inExpand
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