• Publications
  • Influence
Comparative genomic and phylogeographic analysis of Mycobacterium leprae
Reductive evolution and massive pseudogene formation have shaped the 3.31-Mb genome of Mycobacterium leprae, an unculturable obligate pathogen that causes leprosy in humans. The complete genomeExpand
  • 315
  • 26
  • PDF
Detection and Molecular Characterization of 9000-Year-Old Mycobacterium tuberculosis from a Neolithic Settlement in the Eastern Mediterranean
Background Mycobacterium tuberculosis is the principal etiologic agent of human tuberculosis. It has no environmental reservoir and is believed to have co-evolved with its host over millennia. ThisExpand
  • 353
  • 18
  • PDF
Mycobacterium tuberculosis complex DNA from an extinct bison dated 17,000 years before the present.
In order to assess the presence of tuberculosis in Pleistocene bison and the origin of tuberculosis in North America, 2 separate DNA extractions were performed by 2 separate laboratories on samplesExpand
  • 266
  • 11
  • PDF
Tuberculosis: from prehistory to Robert Koch, as revealed by ancient DNA.
During the past 10 years palaeomicrobiology, a new scientific discipline, has developed. The study of ancient pathogens by direct detection of their DNA has answered several historical questions andExpand
  • 171
  • 11
  • PDF
PCR primers that can detect low levels of Mycobacterium leprae DNA.
There are several specific PCR-based methods to detect Mycobacterium leprae DNA, but the amplicons are quite large. For example, primers that target the 36-kDa antigen gene and are in commonExpand
  • 122
  • 8
Co–infection of Mycobacterium tuberculosis and Mycobacterium leprae in human archaeological samples: a possible explanation for the historical decline of leprosy
Both leprosy and tuberculosis were prevalent in Europe during the first millennium but thereafter leprosy declined. It is not known why this occurred, but one suggestion is that cross–immunityExpand
  • 156
  • 8
  • PDF
Tropheryma whippelii DNA in saliva of healthy people
In a random sample of 40 healthy people, 35% showed evidence of Tropheryma whippelii DNA in their saliva. Consistent detection of T. whippelii DNA on repeated sampling suggests that this organism canExpand
  • 133
  • 5
Eighteenth-century genomes show that mixed infections were common at time of peak tuberculosis in Europe
Tuberculosis (TB) was once a major killer in Europe, but it is unclear how the strains and patterns of infection at ‘peak TB' relate to what we see today. Here we describe 14 genome sequences of M.Expand
  • 110
  • 5
  • PDF
Widespread occurrence of Mycobacterium tuberculosis DNA from 18th-19th century Hungarians.
A large number (265) of burials from 1731-1838 were discovered in sealed crypts of the Dominican Church, Vác, Hungary in 1994. Many bodies were naturally mummified, so that both soft tissues andExpand
  • 99
  • 5
  • PDF
Whole-Genome Sequencing for Rapid Susceptibility Testing of M. tuberculosis
1. Fletcher HA, Donoghue HD, Taylor GM, van der Zanden AGM, Spigelman M. Molecular analysis of Mycobacterium tuberculosis DNA from a family of 18th century Hungarians. Microbiology 2003;149:143-51.Expand
  • 93
  • 4