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Exhaustive genotyping of the CEM15 (APOBEC3G) gene and absence of association with AIDS progression in a French cohort.
There were no significant associations between the polymorphisms or haplotypes of CEM15 and a disease progression phenotype in the cohort of HIV-1-seropositive patients with extreme disease progression phenotypes.
Genomic analysis of Th1–Th2 cytokine genes in an AIDS cohort: identification of IL4 and IL10 haplotypes associated with the disease progression
An extensive genetic analysis of IL2, IL4, IL6, IL10, IL12p35 and p40, IL13 and IFNγ genes found no relation with variants of other genes and will facilitate further genetic investigations of Th1–Th2 cytokines in AIDS and other immune-related disorders.
Identification of IL7RA risk alleles for rapid progression during HIV-1 infection: a comprehensive study in the GRIV cohort.
A comprehensive genetic study revealed three SNPs and a risk of haplotype associated with rapid progression to AIDS in the IL7RA gene and Interestingly, the haplotype is composed of SNPs previously identified in other inflammatory diseases by GWAS and by functional studies.
Targeting IL-6 by both passive or active immunization strategies prevents bleomycin-induced skin fibrosis
The results support the relevance of targeting IL-6 in patients with early SSc sinceIL-6 is overexpressed in early stages of the disease and highlight the therapeutic potential of active immunization against IL- 6, which is a seductive alternative to passive immunization.
Exhaustive genotyping of the interferon alpha receptor 1 (IFNAR1) gene and association of an IFNAR1 protein variant with AIDS progression or susceptibility to HIV-1 infection in a French AIDS cohort.
A haplotype of the human CXCR1 gene protective against rapid disease progression in HIV-1+ patients
- A. Vasilescu, Y. Terashima, F. Matsuda
- Biology, MedicineProceedings of the National Academy of Sciences
- 27 February 2007
Results provide strong evidence of a protective role of the CXCR1-Ha allele on disease progression in AIDS, probably acting through modulation of CD4 and CX CR4 expression.
Exhaustive genotyping of the interleukin-1 family genes and associations with AIDS progression in a French cohort.
The IL-1-dependent inflammatory response is likely to play a role in AIDS progression via the regulation ofIL-1Ra expression, and this association will need to be confirmed in other AIDS cohorts, and experiments will also have to be performed to unravel the biological mechanisms at work.
Associations of the IL2Ralpha, IL4Ralpha, IL10Ralpha, and IFN (gamma) R1 cytokine receptor genes with AIDS progression in a French AIDS cohort.
An extensive analysis of Th1/Th2 cytokine receptors IL2Ralpha, IL4R Alpha, IL10R alpha, and IFNgammaR1 gene polymorphisms to evaluate their impact on AIDS progression found weak associations for 13 polymorphisms, but could not relate these positive signals to any relevant biological information on the gene function.
Genomic analysis of Fas and FasL genes and absence of correlation with disease progression in AIDS
It is found that there is no statistically significant association of Fas and FasL polymorphisms and haplotypes with AIDS progression, and the coding regions and promoters of these genes were resequenced in a cohort of 212 HIV-1-seropositive patients presenting extreme disease phenotypes and 155 healthy controls.
Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFα through combined in silico/in vitro/in vivo screening
The ability of low-cost combined in silico/in vitro/in vivo screening approaches to identify orally available small-molecules targeting challenging protein-protein interactions such as homotrimeric TNFα is illustrated.