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Evaluation of the Infinium Methylation 450K technology.
AIMS Studies of DNA methylomes hold enormous promise for biomedicine but are hampered by the technological challenges of analyzing many samples cost-effectively. Recently, a major extension of theExpand
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Regulation of mammalian DNA methyltransferases: a route to new mechanisms
DNA methyltransferases (DNMTs) establish and maintain DNA methylation patterns at specific regions of the genome, thereby contributing to gene regulation. It is becoming evident that an intricate webExpand
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Functional Connection between Deimination and Deacetylation of Histones
ABSTRACT Histone methylation plays key roles in regulating chromatin structure and function. The recent identification of enzymes that antagonize or remove histone methylation offers newExpand
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Exposing the DNA methylome iceberg.
DNA methylation was the first epigenetic modification discovered. Until recently, comprehensive coverage of the composition and distribution of methylated cytosines across the genome was lacking.Expand
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MicroRNAs regulate KDM5 histone demethylases in breast cancer cells.
MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. Alteration of miRNA levels is common in tumors and contributes to the pathogenesis of humanExpand
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Citrullination of DNMT3A by PADI4 regulates its stability and controls DNA methylation
DNA methylation is a central epigenetic modification in mammals, with essential roles in development and disease. De novo DNA methyltransferases establish DNA methylation patterns in specific regionsExpand
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Coordination in a Governmental Disaster Mega-Organization
Disasters, natural or technological, involve an interorganizational response that can take a structural form called the disaster mega-organization (DMO). The discussion will show how this concept isExpand
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Structural and functional properties of thesaurin a (42Sp50), the major protein of the 42 S particles present in Xenopus laevis previtellogenic oocytes.
Thesaurin a is one of two protein components of a 42 S ribonucleoprotein particle that is very abundant in previtellogenic oocytes of Xenopus laevis. The primary function of the 42 S particle is theExpand
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The complexity of technological disaster management: technical, sociopolitical and scientific issues
Technological disaster management is a complex activity. This paper will at tempt to explain the dynamics of this complexity. A case study on a PCB fire in Saint-Basile-le-Grand, Quebec, Canada, wasExpand
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Up‐regulation of 94‐kDa glucose‐regulated protein by hypoxia‐inducible factor‐1 in human endothelial cells in response to hypoxia
Hypoxic environment in solid tumor is known to favor cell survival and to initiate the formation of new capillaries. In this work, we identified by 2D gel analysis 94‐kDa glucose‐regulated proteinExpand
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