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Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism
Keeping the Inflammasome in Check Nucleotide-binding and oligomerization domain (NOD)–like receptors (NLRs) play an important role in the detection of pathogens by cells of the innate immune system.… Expand
Structural basis of ultraviolet-B perception by UVR8
The Arabidopsis thaliana protein UVR8 is a photoreceptor for ultraviolet-B. Upon ultraviolet-B irradiation, UVR8 undergoes an immediate switch from homodimer to monomer, which triggers a signalling… Expand
Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction*
- W. Qin, Tianle Yang, +14 authors G. Pasinetti
- Biology, Medicine
- Journal of Biological Chemistry
- 4 August 2006
Nicotinamide adenine dinucleotide (NAD)+-dependent sirtuins have been identified to be key regulators in the lifespan extending effects of calorie restriction (CR) in a number of species. In this… Expand
DWARF14 is a non-canonical hormone receptor for strigolactone
Classical hormone receptors reversibly and non-covalently bind active hormone molecules, which are generated by biosynthetic enzymes, to trigger signal transduction. The α/β hydrolase DWARF14 (D14),… Expand
The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates
Activation-induced cytidine deaminase (AID) initiates immunoglobulin (Ig) heavy-chain (IgH) class switch recombination (CSR) and Ig variable region somatic hypermutation (SHM) in B lymphocytes by… Expand
L-glutamine provides acid resistance for Escherichia coli through enzymatic release of ammonia
Bacteria, exemplified by enteropathogenic Escherichia coli (E. coli), rely on elaborate acid resistance systems to survive acidic environment (such as the stomach). Comprehensive understanding of… Expand
T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface.
The T cell immunoglobulin mucin (Tim) family of receptors regulates effector CD4(+) T cell functions and is implicated in autoimmune and allergic diseases. Tim-3 induces immunological tolerance, and… Expand
The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1
Abnormal accumulation of triglycerides in the liver, caused in part by increased de novo lipogenesis, results in non-alcoholic fatty liver disease and insulin resistance. Sterol regulatory… Expand
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis.
- P. Xie, Ming-hua Zhang, +17 authors Lingqiang Zhang
- Biology, Medicine
- Nature communications
- 13 May 2014
Neddylation, the covalent attachment of ubiquitin-like protein Nedd8, of the Cullin-RING E3 ligase family regulates their ubiquitylation activity. However, regulation of HECT ligases by neddylation… Expand
Inhibition of caspase-3 activity and activation by protein glutathionylation.
Protein glutathionylation is a post-translational modification that may account for a broad mechanism of redox signaling. The caspase family of cysteine proteases represents a potential target for… Expand