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Apoptosis caused by oxidized LDL is manganese superoxide dismutase and p53 dependent
- R. Kinscherf, Ralf Claus, H. Deigner
- Biology, ChemistryFASEB journal : official publication of the…
- 1 April 1998
Results indicate that in oxLDL‐induced apoptosis, a concomitant induction of p53 and MnSOD is critical, and suggest that it is at least in part due to an enhancement of the sphingomyelin/ ceramide pathway.
Induction of mitochondrial manganese superoxide dismutase in macrophages by oxidized LDL: its relevance in atherosclerosis of humans and heritable hyperlipidemic rabbits
- R. Kinscherf, H. Deigner, J. Metz
- BiologyFASEB journal : official publication of the…
- 1 December 1997
It is concluded that mitochondrial antioxidants such as MnSOD are induced in MΦ in vitro and in atherosclerotic arteries as a reply to increased mitochondrial oxidation.
Metabolomic Analyses of Plasma Reveals New Insights into Asphyxia and Resuscitation in Pigs
This study provides a novel strategy and set of biomarkers that provide biochemical in vivo data that resuscitation with 100% oxygen delays cellular recovery and raises concerns about the safety of 100% O2 resuscitation.
Role of increased sphingomyelinase activity in apoptosis and organ failure of patients with severe sepsis
Patients with severe sepsis exhibit an enhanced sphingolytic activity in comparison with controls, and it is shown that oxidative stress may partially account for the increased activity through posttranslational modification of the enzyme.
Complement C6 deficiency protects against diet-induced atherosclerosis in rabbits.
- W. Schmiedt, R. Kinscherf, S. Bhakdi
- Biology, MedicineArteriosclerosis, thrombosis, and vascular…
- 1 November 1998
It is concluded that the terminal complement sequence is centrally involved in atherosclerotic lesion progression and a dramatic protective effect of C6 deficiency on the development of diet-induced atherosclerosis is documented.
Procalcitonin and CGRP-1 mrna expression in various human tissues.
The complexity of tissue-specific regulation of CALC-I gene expression is demonstrated and a variety of tissues are suppose as a potential source of calcitonin-I-encoded peptides.
Enhanced Association of Platelet-activating Factor Acetylhydrolase with Lipoprotein (a) in Comparison with Low Density Lipoprotein (*)
- C. Blencowe, A. Hermetter, G. Kostner, H. Deigner
- Biology, ChemistryThe Journal of Biological Chemistry
- 29 December 1995
The results suggest that PAF acetylhydrolase exhibits an enhanced association with Lp (a) due to an increased affinity to Lp(a) apolipoprotein B.
Transcriptomic and Proteomic Patterns of Systemic Inflammation in On-Pump and Off-Pump Coronary Artery Bypass Grafting
Gene array and multiplex protein analysis can illuminate the molecular mechanisms responsible for systemic sequelae of CPB and indicate that circulating leukocytes overexpress adhesion and signaling factors after contact with CPB, which potentially facilitates their trapping in the lungs and may promote a subsequent tissue-associated inflammatory response.
Oxidized phospholipids: emerging lipid mediators in pathophysiology
Advances in the knowledge of signalling pathways and interaction partners of oxidized phospholipids will increase the understanding of inflammatory processes and molecular mechanisms of various diseases including atherosclerosis and may play an important role in the development of future therapeutic options or diagnostics.