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Metabolomic Analyses of Plasma Reveals New Insights into Asphyxia and Resuscitation in Pigs
Background Currently, a limited range of biochemical tests for hypoxia are in clinical use. Early diagnostic and functional biomarkers that mirror cellular metabolism and recovery during… Expand
Complexity and pitfalls of mass spectrometry-based targeted metabolomics in brain research.
- M. Urban, David P. Enot, +6 authors H. Deigner
- Chemistry, Medicine
- Analytical biochemistry
- 15 November 2010
Current quantitative metabolomic research in brain tissue is challenged by several analytical issues. To compare data of metabolite pattern, ratios of individual metabolite concentrations and… Expand
Targeted metabolomics for biomarker discovery.
- W. Griffiths, T. Koal, Yuqin Wang, M. Kohl, D. Enot, H. Deigner
- Computer Science, Medicine
- Angewandte Chemie
- 26 July 2010
Metabolomics is a truly interdisciplinary field of science, which combines analytical chemistry, platform technology, mass spectrometry, and NMR spectroscopy with sophisticated data analysis. Expand
Transcriptional regulation of ADAMTS13.
The metalloproteinase ADAMTS13 cleaves VWF multimers instantaneously when they are released from endothelial cells. Absent or manifestly diminished proteolytic activity of ADAMTS13 results in the… Expand
Oxidized Phospholipids in Minimally Modified Low Density Lipoprotein Induce Apoptotic Signaling via Activation of Acid Sphingomyelinase in Arterial Smooth Muscle Cells*
- A. Loidl, Eva Sevcsik, Gernot Riesenhuber, H. Deigner, A. Hermetter
- Biology, Medicine
- Journal of Biological Chemistry
- 29 August 2003
Oxidized phospholipids, including 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine (PGPC) and 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC), typically present in minimally… Expand
Platelet-derived microvesicles induce differential gene expression in monocytic cells: A DNA microarray study
Platelet-derived microvesicles (PMV) that are shed from the plasma membrane of activated platelets, expose various platelet-type antigens on their surface and are able to adhere to other blood cells… Expand
Preprocessing of gene expression data by optimally robust estimators
We describe how optimally robust radius-minimax estimators, i.e. estimators that minimize an asymptotic maximum risk on shrinking neighborhoods about an ideal model, can be used for the aggregation of multiple raw signal intensities to one expression value for Affymetrix and Illumina data. Expand
A smartphone readout system for gold nanoparticle-based lateral flow assays: application to monitoring of digoxigenin
- C. Ruppert, Navneet Phogat, S. Laufer, M. Kohl, H. Deigner
- Materials Science, Medicine
- Microchimica Acta
- 19 January 2019
AbstractFor modern approaches in precision medicine, fast and easy-to-use point-of-care diagnostics (POCs) are essential. Digoxin was chosen as an example of a drug requiring close monitoring.… Expand
Ceramide induces aSMase expression: implications for oxLDL-induced apoptosis
Sphingomyelinase (SMase) stimulation and subsequent ceramide generation are suggested to be involved in signal transduction of stress-induced apoptosis. We now show that apoptosis of human… Expand
HepG2 human hepatoma cells express multiple cytokine genes.
Although cytokines are known to be involved in the regulation of a variety of hepatocellular functions, hepatocytes themselves are generally considered only targets but not producers of these… Expand