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Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.
TLDR
An HLA-DQA1 allele on chromosome 6p21 is most closely associated with idiopathic membranous nephropathy in persons of white ancestry and may facilitate an autoimmune response against targets such as variants of PLA2R1.
Antiphospholipase A2 receptor antibody titer and subclass in idiopathic membranous nephropathy.
TLDR
High agreement between IIFT and ELISA assessments of aPLA(2)R antibody titer and subclass is shown and the pathogenetic role of these antibodies, especially the IgG4 subclass, is highlighted, given the observed relationships between a PLA( 2)R titer, baseline proteinuria, and outcome.
Rituximab for Severe Membranous Nephropathy: A 6-Month Trial with Extended Follow-Up.
TLDR
The data suggest that PLA2R-Ab levels are early markers of rituximab effect and that addition of r ituximabs to NIAT does not affect safety.
PLA2R autoantibodies and PLA2R glomerular deposits in membranous nephropathy.
  • H. Debiec, P. Ronco
  • Medicine, Biology
    The New England journal of medicine
  • 16 February 2011
To the Editor: Membranous nephropathy is a common cause of the nephrotic syndrome in adults. Treatment is controversial and challenging because of the heterogeneity of the disease and a lack of
Kidney biopsy is a sensitive tool for retrospective diagnosis of PLA2R-related membranous nephropathy.
TLDR
Assessment ofPLA2R antigen in biopsy specimens is more sensitive than the serological test for the diagnosis of PLA2R-related MN which can be established retrospectively in case of delayed serum sampling.
Antenatal membranous glomerulonephritis due to anti-neutral endopeptidase antibodies.
The hallmark of membranous glomerulonephritis, a major primary nephropathy, is the presence of immune deposits on the outer aspect of the glomerular basement membrane. The cause of such deposits in...
Anti-Phospholipase A2 Receptor Antibody Titer Predicts Post-Rituximab Outcome of Membranous Nephropathy.
TLDR
Assessing circulating anti-PLA2R autoantibodies and proteinuria may help in monitoring disease activity and guiding personalized rituximab therapy in nephrotic patients with primary MN.
Exostosin 1/Exostosin 2-Associated Membranous Nephropathy.
TLDR
A subset of MN is associated with accumulation of EXT1 and EXT2 in the GBM, which shows features of autoimmune disease, including lupus, in 80.7% of the 26 EXT1/EXT2-associated MN cases identified.
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