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Functional definition and characterization of acute traumatic coagulopathy
Objective:To identify an appropriate diagnostic tool for the early diagnosis of acute traumatic coagulopathy and validate this modality through prediction of transfusion requirements in traumaExpand
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Hemostatic effects of fresh frozen plasma may be maximal at red cell ratios of 1:2.
BACKGROUND Damage control resuscitation targets acute traumatic coagulopathy with the early administration of high-dose fresh frozen plasma (FFP). FFP is administered empirically and as a ratio withExpand
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Factors affecting outcome after traumatic limb amputation
Traumatic leg amputation commonly affects young, active people and leads to poor long‐term outcomes. The aim of this review was to describe common causes of disability and highlight therapeuticExpand
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Epidemiology and outcome of vascular trauma at a British Major Trauma Centre.
OBJECTIVES In the United Kingdom, the epidemiology, management strategies and outcomes from vascular trauma are unknown. The aim of this study was to describe the vascular trauma experience of aExpand
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Elderly patients have similar short term outcomes and five-year survival compared to younger patients after pancreaticoduodenectomy.
BACKGROUND Outcomes following pancreaticoduodenectomy (PD) in elderly patients in the United Kingdom (UK) remain uncertain. This study aimed to analyse peri-operative outcomes in the elderly, andExpand
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Damage control resuscitation using blood component therapy in standard doses has a limited effect on coagulopathy during trauma hemorrhage
ObjectiveTo determine the effectiveness of blood component therapy in the correction of trauma-induced coagulopathy during hemorrhage.BackgroundSevere hemorrhage remains a leading cause of mortalityExpand
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Early changes within the lymphocyte population are associated with the development of multiple organ dysfunction syndrome in trauma patients
BackgroundEarly survival following severe injury has been improved with refined resuscitation strategies. Multiple organ dysfunction syndrome (MODS) is common among this fragile group of patientsExpand
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Trauma-Induced Secondary Cardiac Injury Is Associated With Hyperacute Elevations in Inflammatory Cytokines
Introduction Clinical evidence supports the existence of a trauma-induced secondary cardiac injury. Experimental research suggests inflammation as a possible mechanism. The study aimed to determineExpand
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Clinical and biomarker profile of trauma‐induced secondary cardiac injury
Secondary cardiac injury has been demonstrated in critical illness and is associated with worse outcomes. The aim of this study was to establish the existence of trauma‐induced secondary cardiacExpand
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The influence of peri-operative factors for accelerated discharge following laparoscopic colorectal surgery when combined with an enhanced recovery after surgery (ERAS) pathway.
INTRODUCTION Laparoscopic surgery is well established in the modern management of colorectal disease. More recently, enhanced recovery after surgery (ERAS) protocols have been introduced to furtherExpand
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