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Differential Control of Bmal1 Circadian Transcription by REV-ERB and ROR Nuclear Receptors
Circadian rhythms result from feedback loops involving clock genes and their protein products. In mammals, 2 orphan nuclear receptors, REV-ERBα and RORα, play important roles in the transcription ofExpand
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Ancestral TSH Mechanism Signals Summer in a Photoperiodic Mammal
In mammals, day-length-sensitive (photoperiodic) seasonal breeding cycles depend on the pineal hormone melatonin, which modulates secretion of reproductive hormones by the anterior pituitary glandExpand
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Molecular Circadian Rhythms in Central and Peripheral Clocks in Mammals
The last decade has seen tremendous progress in our understanding of the organization and function of the circadian clock. A number of so‐called clock genes were discovered, and these genes and theirExpand
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Feeding Cues Alter Clock Gene Oscillations and Photic Responses in the Suprachiasmatic Nuclei of Mice Exposed to a Light/Dark Cycle
The suprachiasmatic nuclei (SCN) of the hypothalamus contain the master mammalian circadian clock, which is mainly reset by light. Temporal restricted feeding, a potent synchronizer of peripheralExpand
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Daily and circadian expression of neuropeptides in the suprachiasmatic nuclei of nocturnal and diurnal rodents.
The suprachiasmatic nuclei (SCN) of the hypothalamus are necessary for coordination of major aspects of circadian rhythmicity in mammals. Although the molecular clock mechanism of the SCN has been aExpand
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The nuclear receptor REV‐ERBα is required for the daily balance of carbohydrate and lipid metabolism
Mutations of clock genes can lead to diabetes and obesity. REV‐ERBα, a nuclear receptor involved in the circadian clockwork, has been shown to control lipid metabolism. To gain insight into the roleExpand
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A Molecular Switch for Photoperiod Responsiveness in Mammals
Seasonal synchronization based on day length (photoperiod) allows organisms to anticipate environmental change. Photoperiodic decoding relies on circadian clocks, but the underlying molecularExpand
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Thyroid Hormone and Seasonal Rhythmicity
Living organisms show seasonality in a wide array of functions such as reproduction, fattening, hibernation, and migration. At temperate latitudes, changes in photoperiod maintain the alignment ofExpand
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RFamide‐Related Peptide and its Cognate Receptor in the Sheep: cDNA Cloning, mRNA Distribution in the Hypothalamus and the Effect of Photoperiod
Photoperiodic responses enable animals to adapt their physiology to predictable patterns of seasonal environmental change. In mammals, this depends on pineal melatonin secretion and effects in theExpand
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Per and neuropeptide expression in the rat suprachiasmatic nuclei: compartmentalization and differential cellular induction by light
Per1 and Per2, two clock genes rhythmically expressed in the suprachiasmatic nucleus (SCN), are implicated in the molecular mechanism of the circadian pacemaker and play a major role in itsExpand
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