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Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
TLDR
Genetic and therapeutic antagonism of ANGPTL3 in humans and of Angptl3 in mice was associated with decreased levels of all three major lipid fractions and decreased odds of atherosclerotic cardiovascular disease. Expand
Safety of anacetrapib in patients with or at high risk for coronary heart disease.
TLDR
Treatment with anacetrapib had robust effects on LDL and HDL cholesterol, had an acceptable side-effect profile, and, within the limits of the power of this study, did not result in the adverse cardiovascular effects observed with torcetrapib. Expand
Intensification of statin therapy results in a rapid reduction in atherosclerotic inflammation: results of a multicenter fluorodeoxyglucose-positron emission tomography/computed tomography
TLDR
Statin therapy produced significant rapid dose-dependent reductions in FDG uptake that may represent changes in atherosclerotic plaque inflammation, and FDG-PET imaging may be useful in detecting early treatment effects in patients at risk or with established atherosclerosis. Expand
Recipes for creating animal models of diabetic cardiovascular disease.
TLDR
The consortium has worked to standardize many methods to assess metabolic and cardiovascular end points for measurement of the diabetic state and its macrovascular complications and created a system for sharing both the animal models and the accumulated phenotypic data with the greater scientific community. Expand
Adhesion of Monocytes to Arterial Endothelium and Initiation of Atherosclerosis Are Critically Dependent on Vascular Cell Adhesion Molecule-1 Gene Dosage
TLDR
It is demonstrated that VCAM-1 plays a pivotal role in the initiation of atherosclerosis in Apoe−/− mice by demonstrating a Vcam1 gene-dosage effect and significant reductions in these parameters. Expand
Diabetes Induces Endothelial Dysfunction but Does Not Increase Neointimal Formation in High-Fat Diet Fed C57BL/6J Mice
TLDR
It is suggested that additional diabetes associated parameters (such as hyperlipidemia and atherosclerotic vascular disease) may need to be present to increase neointimal formation in this model of diet induced obesity/diabetes. Expand
Genotype/phenotype relationships in HNF-4alpha/MODY1: haploinsufficiency is associated with reduced apolipoprotein (AII), apolipoprotein (CIII), lipoprotein(a), and triglyceride levels.
TLDR
It is shown that HNF-4alpha haploinsufficiency rather than hyperglycemia is the primary cause of decreased serum protein and triglyceride concentrations, and that genetic or environmental modifiers other than HNF -4alpha do not appear to contribute to the observed decrease of H NF-4 alpha-regulated serum proteins. Expand
In Silico Quantitative Trait Locus Map for Atherosclerosis Susceptibility in Apolipoprotein E–Deficient Mice
TLDR
A public mouse single nucleotide polymorphism (SNP) database was used to define the genetic loci that are associated with this trait, without the need to perform strain intercrosses, to confirm the presence and identity of atherosclerosis susceptibility genes within these loci. Expand
Design of the DEFINE trial: determining the EFficacy and tolerability of CETP INhibition with AnacEtrapib.
TLDR
Determining the EFficacy and Tolerability of CETP INhibition with AnacEtrapib is a randomized, double-blind, placebo-controlled trial to assess the efficacy and safety profile of anacetrapib in patients with coronary heart disease (CHD) or CHD risk equivalents. Expand
Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model
TLDR
Strong evidence for complex inheritance of atherosclerosis in mice with elevated plasma low density lipoprotein cholesterol and a major influence of nonlipoprotein-related factors on disease susceptibility is provided. Expand
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