• Publications
  • Influence
The investigation with which this paper deals started with the observation, that certain specimens of ergot and its extracts exhibited a type of action which was clearly not referabie to any of the
The physiological action of β‐iminazolylethylamine
,8-IMINAZOLYLETHYLAMINE is the amine which is produced when carbon dioxide is split off from histidine. It was first prepared synthetically by Windaus and Vogt'. Recently Ackermann2 obtained a large
Chemical structure and sympathomimetic action of amines
The elucidation of the structure of the active principle of the stupra-renal medulla by the work of Abell and its synthesis by Stolz 7 and by Dakin8 led to the physiological investigation of substances nearly related to it in chemical structure.
The presence of histamine and acetylcholine in the spleen of the ox and the horse
It appeared to us desirable to apply the methods successfully used in the cases already investigated, to the extract of one additional organ, namely the spleen, and to warrant a more general presumption that, when activity of either of these types can be clearly demonstrated in an extract from any fresh animal organ, it is probably due to the presence of the corresponding simple basic principle.
On some physiological actions of ergot
  • H. Dale
  • Chemistry
    The Journal of physiology
  • 31 May 1906
The facts make it impossible to speak of the action any longer as that of chrysotoxin, as the introduction of new names on the strength of physiological results, and in default of chemical isolation of principles, would inevitably add to the existing confusion.
Further observations on the action of β‐iminazolylethylamine
The mammalian carnivora are the only animals in which a vaso-dilator action of sympathetic nerves and of adrenine has been observed after injection of ergotoxine, and it is found that the monkey and the fowl respond to intravenous injection of 8-I.
Reactions of denervated voluntary muscle, and their bearing on the mode of action of parasympathetic and related nerves
The recent careful review by Gasser of work on these contracture responses of denervated muscles makes it unnecessary for us to give a connected historical survey; the authors need only refer, in their proper places, to earlier observations bearing on their own.