• Publications
  • Influence
Anti factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome.
The atypical form of the kidney disease hemolytic uremic syndrome (aHUS) is associated with defective complement regulation. In addition to mutations in complement regulators, factor H (FH)-specificExpand
  • 223
  • 7
  • PDF
Botryorhodines A-D, antifungal and cytotoxic depsidones from Botryosphaeria rhodina, an endophyte of the medicinal plant Bidens pilosa.
An endophytic fungus (Botryosphaeria rhodina) was isolated from the stems of the medicinal plant Bidens pilosa (Asteraceae) that is known for its anti-inflammatory, antiseptic and antifungal effects.Expand
  • 77
  • 7
Growth of keratinocytes on porous films of poly(3-hydroxybutyrate) and poly(4-hydroxybutyrate) blended with hyaluronic acid and chitosan.
  • G. Peschel, H. Dahse, +4 authors M. Roth
  • Materials Science, Medicine
  • Journal of biomedical materials research. Part A
  • 15 June 2008
The objective of this study was to develop novel absorbable films suitable for use as a tissue-engineering scaffold for keratinocytes as a therapy for replacement of damaged skin.Expand
  • 52
  • 4
Antimicrobial and anti-inflammatory activity of four known and one new triterpenoid from Combretum imberbe (Combretaceae).
Combretum imberbe is used widely in Africa inter alia for treating bacterial infections. In addition to four known triterpenoids, 1alpha,3beta-dihydroxy-12-oleanen-29-oic (1),Expand
  • 61
  • 4
Conidial Dihydroxynaphthalene Melanin of the Human Pathogenic Fungus Aspergillus fumigatus Interferes with the Host Endocytosis Pathway
Aspergillus fumigatus is the most important air-borne fungal pathogen of humans. The interaction of the pathogen with the host's immune system represents a key process to understand pathogenicity.Expand
  • 106
  • 3
Cleavage of four carbon-carbon bonds during biosynthesis of the griseorhodin a spiroketal pharmacophore.
The rubromycins, such as gamma-rubromycin, heliquinomycin, and griseorhodin A, are a family of extensively modified aromatic polyketides that inhibit HIV reverse transcriptase and human telomerase.Expand
  • 45
  • 3
New abietane diterpenoids from the mangrove Avicennia marina.
Phytochemical investigations of the twigs of Avicennia marina yielded three new abietane diterpenoids 11-hydroxy-8,11,13-abietatriene 12- O-beta-xylopyranoside ( 1), and a pair of inseparable epimersExpand
  • 23
  • 3
  • PDF
Synthesis and characterization of novel 1,2,4-triazine derivatives with antiproliferative activity.
A series of novel small molecules with a 1,2,4-triazine scaffold was obtained according to a recently published and highly efficient synthetic route. Screening for antiproliferative and cytotoxicExpand
  • 55
  • 2
In vitro cytotoxicity of melleolide antibiotics: structural and mechanistic aspects.
Melleolide sesquiterpene aryl esters are secondary products of the mushroom genus Armillaria. We compared the cytotoxicity of eleven melleolides--five thereof are new natural products--against fourExpand
  • 35
  • 2
Terpenes from the Soft Corals Litophyton arboreum and Sarcophyton ehrenbergi
The new cembrane diterpene (3E,11E)‐cembra‐3,8(19),11,15‐tetraene‐7α‐ol (1), nephthenol (2), and all‐trans‐peridinin (3) have been isolated from the soft coral Litophyton arboreum. The tetraterpeneExpand
  • 28
  • 2