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Do Nitroxide Antioxidants Act as Scavengers of O2 or as SOD Mimics?*
Stable nitroxide radicals were reported to act as SOD mimics and catalyze the dismutation of O2 through two different catalytic pathways including reductive and oxidative reaction mechanisms (Samuni,Expand
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Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy.
Numerous mechanism-based anticancer drugs that target the phosphatidylinositol 3-kinase (PI3K) pathway are in clinical trials. However, it remains challenging to assess responses by traditionalExpand
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Overexpression of vascular endothelial growth factor 165 drives peritumor interstitial convection and induces lymphatic drain: magnetic resonance imaging, confocal microscopy, and histological
Increased expression of vascular endothelial growth factor (VEGF) has been associated with increased lymph node metastases. The aim of this work was to determine whether VEGF-inducedExpand
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Ferritin as an endogenous MRI reporter for noninvasive imaging of gene expression in C6 glioma tumors.
The heavy chain of murine ferritin, an iron storage molecule with ferroxidase activity, was developed as a novel endogenous reporter for the detection of gene expression by magnetic resonance imagingExpand
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Lysyl oxidase-related protein-1 promotes tumor fibrosis and tumor progression in vivo.
The lysyl oxidase gene family members function as extracellular matrix modulating enzymes. We have found that another member of this family, lysyl oxidase related protein-1 (LOR-1), is highlyExpand
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In Vivo Prediction of Vascular Susceptibility to Vascular Endothelial Growth Factor Withdrawal Magnetic Resonance Imaging of C6 Rat Glioma in Nude Mice
One of the hallmarks of tumor neovasculature is the prevalence of immature vessels manifested by the low degree of recruitment of vascular mural cells such as pericytes and smooth muscle cells. ThisExpand
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Vascular Remodeling and Angiogenesis in Ectopic Ovarian Transplants: A Crucial Role of Pericytes and Vascular Smooth Muscle Cells in Maintenance of Ovarian Grafts1
Abstract Cancer patients, treated by either chemo- or radiotherapy, frequently suffer from ovarian failure and infertility. One of the new emerging techniques to preserve reproductive potential ofExpand
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Flower and Nectar Characteristics of Nine Species of Labiatae and their influence on Honeybee Visits
SummaryThe anatomy of the nectary, the relative amount of nectar secreted, the composition of the nectar and its sugar concentration, were studied in 9 species of the family, Labiatae (CoridothymusExpand
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In vivo BOLD contrast MRI mapping of subcutaneous vascular function and maturation: validation by intravital microscopy.
Bold contrast MRI was applied for mapping vascular maturation in tumor- and wound-induced skin angiogenesis using the response of mature vessels to hypercapnia (inhalation of air vs. air 5% CO(2))Expand
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MRI and fluorescence microscopy of the acute vascular response to VEGF165: vasodilation, hyper-permeability and lymphatic uptake, followed by rapid inactivation of the growth factor.
Vascular endothelial growth factor (VEGF) is one of the key growth factors regulating tumor angiogenesis and thus it is one of the primary targets for antiangiogenic therapy. The long-term effects ofExpand
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