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A role for human endogenous retrovirus‐K (HML‐2) in rheumatoid arthritis: investigating mechanisms of pathogenesis
- G. Freimanis, P. Hooley, +8 authors P. Nelson
- Clinical and experimental immunology
- 1 June 2010
Human endogenous retroviruses (HERVs) are remnants of ancient retroviral infections within the human genome. These molecular fossils draw parallels with present‐day exogenous retroviruses and have… Expand
Molecular investigations implicate human endogenous retroviruses as mediators of anti-retroviral antibodies in autoimmune rheumatic disease.
Polymerase chain reaction using specific primers, failed to detect HTLV-I amplicons in patients with rheumatic diseases previously shown to possess antibodies to retroviral products. However, by… Expand
The potential role of human endogenous retrovirus K10 in the pathogenesis of rheumatoid arthritis: a preliminary study.
- H. D. Ejtehadi, G. L. Freimanis, +5 authors P. Nelson
- Annals of the rheumatic diseases
- 1 May 2006
OBJECTIVE To examine whether human endogenous retrovirus K10 is associated with autoimmune rheumatic disease. DESIGN A novel multiplex reverse transcription polymerase chain reaction (RT-PCR)… Expand
Rheumatoid Arthritis is Associated with IgG Antibodies to Human Endogenous Retrovirus Gag Matrix: A Potential Pathogenic Mechanism of Disease?
Objective. Human endogenous retrovirus (HERV)-K10 has been implicated in the etiology and pathogenesis of rheumatoid arthritis (RA). A secondary immune response to this virus might suggest an… Expand