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Biological Basis of Sex Differences in the Propensity to Self-administer Cocaine
Women are at greater risk for cocaine addiction than are men, and female rats similarly show a greater propensity to self-administer cocaine than do male rats. This could be due to the intrinsic sexExpand
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Renewal of drug seeking by contextual cues after prolonged extinction in rats.
Contextual stimuli associated with drug exposure can modulate various effects of drugs, but little is known about their role in relapse to drug seeking. Using a renewal procedure, the authors reportExpand
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Neural and Behavioral Plasticity Associated with the Transition from Controlled to Escalated Cocaine Use
BACKGROUND Rats given extended access to cocaine develop several symptoms of addiction, including a gradual escalation of drug intake, whereas rats given limited access do not. We asked here whetherExpand
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Context-induced relapse to drug seeking: a review
In humans, exposure to environmental contexts previously associated with drug intake often provokes relapse to drug use, but the mechanisms mediating this relapse are unknown. Based on early studiesExpand
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Effect of Dopamine Receptor Antagonists on Renewal of Cocaine Seeking by Reexposure to Drug-associated Contextual Cues
We recently found that in rats trained to self-administer a heroin-cocaine mixture, exposure to the drug self-administration environment, after extinction of the drug-reinforced behavior in aExpand
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Modulation of the Induction or Expression of Psychostimulant Sensitization by the Circumstances Surrounding Drug Administration
The conditions necessary to induce psychomotor sensitization and to promote its expression are not well understood. Two examples are reviewed here of how the circumstances surrounding drugExpand
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Opposite effects of amphetamine self-administration experience on dendritic spines in the medial and orbital prefrontal cortex.
We studied the long-term effects of amphetamine self-administration experience (or sucrose reward training) on dendritic morphology (spine density) in nucleus accumbens (Nacc), medial (MPC) andExpand
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Incentive Learning Underlying Cocaine-Seeking Requires mGluR5 Receptors Located on Dopamine D1 Receptor-Expressing Neurons
Understanding the psychobiological basis of relapse remains a challenge in developing therapies for drug addiction. Relapse in cocaine addiction often occurs following exposure to environmentalExpand
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Context‐specific sensitization of cocaine‐induced locomotor activity and associated neuronal ensembles in rat nucleus accumbens
Repeated cocaine administration to rats outside their home cage induces behavioral sensitization that is strongly modulated by the drug administration environment. We hypothesized that stimuli in theExpand
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Sensitization of Psychomotor Stimulation and Conditioned Reward in Mice: Differential Modulation by Contextual Learning
Incentive motivation theory ascribes a critical role to reward-associated stimuli in the generation and maintenance of goal-directed behavior. Repeated psychomotor stimulant treatment, in addition toExpand
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