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Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice.
It is reported that gamma-aminobutyric acidA (GABA(A) receptor alpha1-/- mice exhibit postural and kinetic tremor and motor incoordination that is characteristic of essential tremor disease, and a mechanism of GABAergic dysfunction in the major motor pathway is elucidated.
Effects of ethanol on ion channels.
Genetic essential tremor in ?-aminobutyric acidA receptor a1 subunit knockout mice
It is reported that γ-aminobutyric acidA (GABAA) receptor α1–/– mice exhibit postural and kinetic tremor and motor incoordination that is characteristic of essential tremor disease.
Suppression of alcohol intake after administration of the Chinese herbal medicine, NPI-028, and its derivatives.
NPI-028 and one of its pure components, NPI-031G, selectively reduced alcohol intake in alcohol-preferring rats and significantly reduced ethanol intake in FH rats without affecting food or water intake.
The role of protein kinase A in the ethanol-induced increase in spontaneous GABA release onto cerebellar Purkinje neurons.
Ethanol increases miniature inhibitory postsynaptic current frequency and decreases the paired-pulse ratio, which suggests that ethanol increases both spontaneous and evoked GABA release, respectively, and the mechanism of the cannabinoid-mediated decrease in spontaneous GABA release involves internal calcium stores and PKA.
Competing presynaptic and postsynaptic effects of ethanol on cerebellar purkinje neurons.
Examination of the interplay of presynaptic and postsynaptic mechanisms in cerebellar Purkinje neurons shows a dual action of ethanol, which acts presynaptically to increase inhibition by release of GABA, while simultaneously acting postsynaptic to increase intrinsic excitatory drive.
A Conceptualization of Integrated Actions of Ethanol Contributing to its GABAmimetic Profile: A Commentary
It is hypothesized that the GABAmimetic profile for ethanol is due to activation of mechanisms associated with GABA function, distinct from a direct action on the majority of postsynaptic GABAA receptors.
Calcium Release from Presynaptic Internal Stores Is Required for Ethanol to Increase Spontaneous γ-Aminobutyric Acid Release onto Cerebellum Purkinje Neurons
Calcium release from presynaptic internal stores plays a vital role in the mechanism of ethanol-enhanced spontaneous GABA release at the interneuron-Purkinje cell synapse, and retrograde messengers are not involved.