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Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice.
Essential tremor is the most common movement disorder and has an unknown etiology. Here we report that gamma-aminobutyric acidA (GABA(A)) receptor alpha1-/- mice exhibit postural and kinetic tremorExpand
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Effects of ethanol on ion channels.
Ion channels play critical roles in nervous system function, from initiating rapid synaptic activity to propagation of action potentials. Studies have indicated that many of the effects of ethanol onExpand
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Calcium Release from Presynaptic Internal Stores Is Required for Ethanol to Increase Spontaneous γ-Aminobutyric Acid Release onto Cerebellum Purkinje Neurons
Recent data have demonstrated that ethanol increases γ-aminobutyric acid (GABA) release in many brain regions, but little is known about the mechanism responsible for this action. Consistent withExpand
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Genetic essential tremor in ?-aminobutyric acidA receptor a1 subunit knockout mice
Essential tremor is the most common movement disorder and has an unknown etiology. Here we report that γ-aminobutyric acidA (GABAA) receptor α1–/– mice exhibit postural and kinetic tremor and motorExpand
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The neonate-6-hydroxydopamine-lesioned rat: a model for clinical neuroscience and neurobiological principles
In 1973, a technique of administering 6-hydroxydopamine (2,4,5-trihydroxyphenylethylamine) intracisternally to neonate rats was introduced to selectively reduce brain dopamine (neonate-lesioned rat).Expand
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Therapeutic liabilities of in vivo viral vector tropism: adeno-associated virus vectors, NMDAR1 antisense, and focal seizure sensitivity.
The N-methyl-D-aspartic acid (NMDA) receptor provides a potential target for gene therapy of focal seizure disorders. To test this approach, we cloned a 729-bp NMDA receptor (NMDAR1) cDNA fragment inExpand
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The role of protein kinase A in the ethanol-induced increase in spontaneous GABA release onto cerebellar Purkinje neurons.
Ethanol increases miniature inhibitory postsynaptic current frequency and decreases the paired-pulse ratio, which suggests that ethanol increases both spontaneous and evoked GABA release,Expand
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Competing presynaptic and postsynaptic effects of ethanol on cerebellar purkinje neurons.
BACKGROUND Ethanol has actions on cerebellar Purkinje neurons that can result either in a net excitation or in inhibition of neuronal activity. The present study examines the interplay of presynapticExpand
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Suppression of alcohol intake after administration of the Chinese herbal medicine, NPI-028, and its derivatives.
The Chinese herbal medicine, NPI-028, has been used for centuries in China to counteract alcohol intoxication. The present study used a number of different experimental conditions to determineExpand
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A Conceptualization of Integrated Actions of Ethanol Contributing to its GABAmimetic Profile: A Commentary
Early behavioral investigations supported the contention that systemic ethanol displays a GABAmimetic profile. Microinjection of GABA agonists into brain and in vivo electrophysiological studiesExpand
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