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A standardized protocol for repeated social defeat stress in mice
A major impediment to novel drug development has been the paucity of animal models that accurately reflect symptoms of affective disorders. In animal models, prolonged social stress has proven to beExpand
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Histone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli
Previous work has identified alterations in histone acetylation in animal models of drug addiction and depression. However, the mechanisms which integrate drugs and stress with changes in chromatinExpand
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Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
Despite abundant expression of DNA methyltransferases (Dnmts) in brain, the regulation and behavioral role of DNA methylation remain poorly understood. We found that Dnmt3a expression was regulatedExpand
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Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity
Cocaine Addiction and Histone Methylation Long-lasting behavioral syndromes associated with chronic cocaine exposure may result from dysregulation of the global transcriptional machinery. Maze et al.Expand
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Genome-wide Analysis of Chromatin Regulation by Cocaine Reveals a Role for Sirtuins
Changes in gene expression contribute to the long-lasting regulation of the brain's reward circuitry seen in drug addiction; however, the specific genes regulated and the transcriptional mechanismsExpand
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Social stress, therapeutics and drug abuse: preclinical models of escalated and depressed intake.
The impact of ostensibly aversive social stresses on triggering, amplifying and prolonging intensely rewarding drug taking is an apparent contradiction in need of resolution. Social stressExpand
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Cell Type–Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward
BDNF, Dopamine, and Cocaine Reward The nucleus accumbens plays a crucial role in mediating the rewarding effects of drugs of abuse. Different subpopulations of nucleus accumbens projection neuronsExpand
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ΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses
In contrast with the many studies of stress effects on the brain, relatively little is known about the molecular mechanisms of resilience, the ability of some individuals to escape the deleteriousExpand
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Antidepressant Actions of Histone Deacetylase Inhibitors
Persistent symptoms of depression suggest the involvement of stable molecular adaptations in brain, which may be reflected at the level of chromatin remodeling. We find that chronic social defeatExpand
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Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex
Brain stimulation and imaging studies in humans have highlighted a key role for the prefrontal cortex in clinical depression; however, it remains unknown whether excitation or inhibition ofExpand
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