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Measuring and using light in the melanopsin age
A new light-measurement strategy taking account of the complex photoreceptive inputs to these non-visual responses is proposed for use by researchers, and simple suggestions for artificial/architectural lighting are provided for regulatory authorities, lighting manufacturers, designers, and engineers. Expand
Phylogenetic relations between microbats, megabats and primates (Mammalia: Chiroptera and Primates).
We examine the paraphylectic hypothesis of bat origins, both in the light of previous discussions, and in the light of new evidence from our analyses of neurological traits and wing morphology.Expand
Diurnal transcriptome atlas of a primate across major neural and peripheral tissues
The daily expression rhythms in >80% of protein-coding genes, encoding diverse biochemical and cellular functions, constitutes by far the largest regulatory mechanism that integrates diverse biochemical functions within and across cell types. Expand
Melanopsin-Dependent Nonvisual Responses: Evidence for Photopigment Bistability In Vivo
It is found that prestimulation with long-wavelength light not only restores but enhances single-unit responses of SCN neurons to 480-nm light, whereas the long-Wavelength stimulus alone fails to elicit any response. Expand
Visual system of a naturally microphthalmic mammal: The blind mole rat, Spalax ehrenbergi
Retinal projections and visual thalamo‐cortical connections were studied in the subterranean mole rat, belonging to the superspecies Spalax ehrenbergi, by anterograde and retrograde tracingExpand
Modeling the Role of Mid-Wavelength Cones in Circadian Responses to Light
It is shown that rod and cone photoreceptors play a significant role in light entrainment and in phase shifting of the circadian oscillator using a mouse model that specifically lacks mid-wavelength cones. Expand
Ocular regression conceals adaptive progression of the visual system in a blind subterranean mammal
It is reported here that severe regression of thalamic and tectal structures involved in form and motion perception is coupled to a selective hypertrophy of structures subserving photoperiodic functions and can be explained as an adaptive response to the underground environment. Expand
Melanopsin Bistability: A Fly's Eye Technology in the Human Retina
The results suggest that the human retina exploits fly-like photoreceptive mechanisms that are potentially important for the modulation of non-visual responses to light and highlights the ubiquitous nature of photoswitchable photosensors across living organisms. Expand
Retinal projections in mice with inherited retinal degeneration: Implications for circadian photoentrainment
Pseudorabies virus is used as a neuroanatomical tract tracer in mice to address a series of questions about which retinal cells mediate circadian responses to light and the nature of the retinohypothalamic projection. Expand
Effects of Irradiance and Stimulus Duration on Early Gene Expression (Fos) in the Suprachiasmatic Nucleus: Temporal Summation and Reciprocity
This report provides the first demonstration that the mechanism of photon integration by the circadian system is expressed at a cellular level in the SCN, and that integration occurs over a range of 5 log units of photon number. Expand