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The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis
RBM and DAZ/SPGY are two families of genes located on the Y chromosome that encode proteins containing RNA-binding motifs, and both have been described as candidate human spermatogenesis genes.… Expand
Mouse HORMAD1 and HORMAD2, Two Conserved Meiotic Chromosomal Proteins, Are Depleted from Synapsed Chromosome Axes with the Help of TRIP13 AAA-ATPase
Meiotic crossovers are produced when programmed double-strand breaks (DSBs) are repaired by recombination from homologous chromosomes (homologues). In a wide variety of organisms, meiotic… Expand
The DAZL family proteins are PABP‐binding proteins that regulate translation in germ cells
- B. Collier, B. Gorgoni, C. Loveridge, H. Cooke, N. K. Gray
- Biology, Medicine
- The EMBO journal
- 20 July 2005
DAZL proteins are germ‐cell‐specific RNA‐binding proteins essential for gametogenesis. The precise molecular role of these proteins in germ‐cell development remains enigmatic; however, they appear to… Expand
Cloning of human satellite III DNA: different components are on different chromosomes.
Two fragments cloned from purified human satellite III DNA do not cross-react with each other. One fragment, for which a partial sequence is reported, hybridises to satellite II as well as III and is… Expand
Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1
Meiotic crossover formation between homologous chromosomes (homologues) entails DNA double-strand break (DSB) formation, homology search using DSB ends, and synaptonemal-complex formation coupled… Expand
Dazl binds in vivo to specific transcripts and can regulate the pre-meiotic translation of Mvh in germ cells.
- N. Reynolds, B. Collier, +6 authors H. Cooke
- Medicine, Biology
- Human molecular genetics
- 15 December 2005
Gametogenesis is a complex process subject to strict controls at both levels of transcription and translation. Members of a family of conserved RNA-binding proteins encoded by the DAZ genes are… Expand
A gradient of sex linkage in the pseudoautosomal region of the human sex chromosomes
- F. Rouyer, M. Simmler, C. Johnsson, G. Vergnaud, H. Cooke, J. Weissenbach
- Biology, Medicine
- 23 January 1986
Three independent pseudoautosomal loci are linked to sex determination at frequencies which define a gradient of linkage. The segregation patterns of these loci indicate that X/Y recombination… Expand
Absence of mDazl produces a final block on germ cell development at meiosis.
The autosomal gene DAZL is a member of a family of genes (DAZL, DAZ, BOULE), all of which contain a consensus RNA binding domain and are expressed in germ cells. Adult male and female mice null for… Expand
A Novel Mouse Synaptonemal Complex Protein Is Essential for Loading of Central Element Proteins, Recombination, and Fertility
The synaptonemal complex (SC) is a proteinaceous, meiosis-specific structure that is highly conserved in evolution. During meiosis, the SC mediates synapsis of homologous chromosomes. It is essential… Expand
A murine homologue of the human DAZ gene is autosomal and expressed only in male and female gonads.
We have isolated a homologue of the human Y linked DAZ (deleted in azoospermia) gene from mouse. This gene, Dazla (Daz like, autosomal), is autosomal, located on chromosome 17 and apparently single… Expand