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Formation of anhydrosugars in the chemical depolymerization of heparin.
In the reactions used to break heparin down to mono- and oligosaccharides, androsugars are formed at two stages. The first of these is the well-known cleavage of heparin with nitrous acid to convertExpand
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Heparin-Binding Proteins
Preface. Conventions, Abbreviations, And Terminology. Heparin Vs. Heparan Sulfate. Structures of Heparinoids. Experimental Approaches for Determining Heparinoid Structures. Structural Modification ofExpand
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Mixed function oxidation. 3. An electron transport complex in camphor ketolactonization.
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Involvement of phosphatidylinositol and insulin in the coordinate regulation of proteoheparan sulfate metabolism and hepatocyte growth.
A rat hepatocyte cell line was cultured in Higuchi's medium with fetal calf serum and insulin and labeled with 35SO2/4-. The cells were treated with a number of ligands to displace the heparan 35SO4Expand
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Control of cell division in hepatoma cells by exogenous heparan sulfate proteoglycan
The effects of cell surface heparan sulfate proteoglycan (HSPG) prepared from log and confluent monolayers of a rat hepatoma cell line on hepatoma cell growth were studied. When HSPG isolated fromExpand
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The disaccharide composition of heparins and heparan sulfates.
Heparin and heparan sulfate can be cleaved selectively at their N-sulfated glucosamine residues by direct treatment with nitrous acid at pH 1.5. These polymers can also be cleaved selectively atExpand
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Structural analysis of periodate-oxidized heparin.
  • H. Conrad, Y. Guo
  • Biology, Medicine
  • Advances in experimental medicine and biology
  • 1992
Treatment of heparin with HONO at pH 1.5 cleaves the polymer at N-sulfated, but not at N-acetylated GlcN residues, and yields di- and tetrasaccharides. The GlcNSO3 residues at the sites of cleavageExpand
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Structural characterization of the oligosaccharides formed by depolymerization of heparin with nitrous acid.
Heparin was cleaved with nitrous acid at pH 1.5 and the products were reduced with Na+ boro[3H]hydride to generate a mixture of di- and tetrasaccharides having anhydro-D-[3H]mannitol (AManR) residuesExpand
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