• Publications
  • Influence
The molecular basis of CaMKII function in synaptic and behavioural memory
Long-term potentiation (LTP) in the CA1 region of the hippocampus has been the primary model by which to study the cellular and molecular basis of memory. Calcium/calmodulin-dependent protein kinaseExpand
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Dendritic Dynamics In Vivo Change during Neuronal Maturation
In vivo imaging of optic tectal neurons in the intactXenopus tadpole permits direct observation of the structural dynamics that occur during dendritic arbor formation. Based on images of singleExpand
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Nitric Oxide Is an Essential Negative Regulator of Cell Proliferation in Xenopus Brain
Mechanisms controlling the transition of a neural precursor cell from proliferation to differentiation during brain development determine the distinct anatomical features of the brain. Nitric oxideExpand
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In Vivo Time-Lapse Imaging and Serial Section Electron Microscopy Reveal Developmental Synaptic Rearrangements
Dendrites, axons, and synapses are dynamic during circuit development; however, changes in microcircuit connections as branches stabilize have not been directly demonstrated. By combining in vivoExpand
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The scaffold protein, Homer1b/c, regulates axon pathfinding in the central nervous system in vivo
Homer proteins are a family of multidomain cytosolic proteins that have been postulated to serve as scaffold proteins that affect responses to extracellular signals by regulating protein–proteinExpand
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Sperry and Hebb: oil and vinegar?
  • H. Cline
  • Biology, Medicine
  • Trends in Neurosciences
  • 1 December 2003
The interface between so-called activity-dependent and activity-independent mechanisms of circuit development is discussed here in light of recent findings that question the role of activity in brainExpand
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Synaptogenesis: A Balancing Act between Excitation and Inhibition
  • H. Cline
  • Biology, Medicine
  • Current Biology
  • 29 March 2005
Recent studies have implicated a number of membrane-associated proteins, including the signaling pair neuroligin and beta-neurexin, in synapse formation, suggesting that they govern the ratio ofExpand
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Synaptic Plasticity: Importance of Proteasome-Mediated Protein Turnover
  • H. Cline
  • Biology, Medicine
  • Current Biology
  • 1 July 2003
The ubiquitin-proteasome system regulates protein degradation in every eukaryotic cell. Recent work has shown that protein turnover mediated by the ubiquitin-proteasome system plays a key role inExpand
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Grand Challenges for Global Brain Sciences
The next grand challenges for society and science are in the brain sciences. A collection of 60+ scientists from around the world, together with 10+ observers from national, private, and foundations,Expand
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An advanced applications tool to enhance the fuse protection of power semiconductors
  • R. Wilkins, H. Cline
  • Engineering, Materials Science
  • Conference Record of the IEEE Industry…
  • 2 October 1993
A program called the Fuse Analysis Program (FAP) is described which has been developed for a fuse manufacturer's applications engineers and which uses deterministic models to compute the actualExpand
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