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The Modified Mini-Mental State (3MS) examination.
The Modified Mini-Mental State (3MS) incorporates four added test items, more graded scoring, and some other minor changes to sample a broader variety of cognitive functions, cover a wider range of difficulty levels, and enhance the reliability and the validity of the scores.
Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association
This scientific statement provides an overview of the evidence on vascular contributions to cognitive impairment and dementia and provides evidence that subcortical forms of VCI with white matter hyperintensities and small deep infarcts are common and risk markers for VCI are the same as traditional risk factors for stroke.
Practice parameter: Diagnosis of dementia (an evidence-based review)
D diagnostic criteria for dementia have improved since the 1994 practice parameter, and further research is needed to improve clinical definitions of dementia and its subtypes, as well as to determine the utility of various instruments of neuroimaging, biomarkers, and genetic testing in increasing diagnostic accuracy.
Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two…
Subcortical ischaemic vascular dementia
Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases.
In AD, neuronal loss was most severe and best correlated with the duration of illness in the LC, rather than in NB as traditionally expected, suggesting that the former 2 nuclei may share common pathogenetic susceptibilities.
Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease
- A. Du, N. Schuff, M. Weiner
- Biology, PsychologyJournal of neurology, neurosurgery, and…
- 1 October 2001
Using ERC and hippocampus together improved discrimination between AD and CN but did not improve discrimination between MCI and NC; the ERC was better than the hippocampus for distinguishing MCI from AD.
The Uniform Data Set (UDS): Clinical and Cognitive Variables and Descriptive Data From Alzheimer Disease Centers
- J. Morris, S. Weintraub, W. Kukull
- PsychologyAlzheimer disease and associated disorders
- 1 October 2006
A Clinical Task Force, composed of clinical leaders from Alzheimer's Disease Centers (ADC), was convened by the National Institute on Aging to develop a uniform set of assessment procedures to…
Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease
Assessment of the cingulum fibers using diffusion tensor imaging may aid early diagnosis of Alzheimer disease.