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Santamarin, a sesquiterpene lactone isolated from Saussurea lappa, represses LPS-induced inflammatory responses via expression of heme oxygenase-1 in murine macrophage cells.
The data suggest that the anti-inflammatory effect of santamarin in macrophages may be exerted through a novel mechanism that involves HO-1 expression, which plays a cytoprotective role against inflammation.
Suppression of dust mite extract and 2,4-dinitrochlorobenzene-induced atopic dermatitis by the water extract of Lindera obtusiloba.
ETHNOPHARMACOLOGICAL RELEVANCE The Lindera obtusiloba has been used in traditional medicine for the treatment of inflammation and dermatitis. In this study, we investigated the effect of topical
Chemical constituents of Cynanchum wilfordii and the chemotaxonomy of two species of the family Asclepiadacease, C. wilfordii and C. auriculatum
A phytochemical study on the roots of C. wilfordii found compounds 15, 16, 18, 19, and 20 were isolated for the first time from this species, and conduritol F was demonstrated to be contained only in C.Wilfordii.
Cinnamomulactone, a new butyrolactone from the twigs of Cinnamomum cassia and its inhibitory activity of matrix metalloproteinases
Cinnamomulactone (1), a new butyrolactone was isolated from the twigs of C. cassia together with nine known compounds, which showed inhibitory activity against matrix metalloproteinases (MMPs) gene expression and compound 1 has been revealed to suppress the gene expression of MMP-3 and interleukin (IL)-1β in tumor necrosis factor stimulated rheumatoid arthritis synovial fibroblasts.
Tyrosol attenuates lipopolysaccharide-induced acute lung injury by inhibiting the inflammatory response and maintaining the alveolar capillary barrier.
Acute lung injury (ALI) is a life-threatening disease characterized by increased pulmonary vascular permeability because of alveolar capillary barrier dysfunction and increased immune responses. This
Sauchinone suppresses pro-inflammatory mediators by inducing heme oxygenase-1 in RAW264.7 macrophages.
Results suggest that sauchinone inhibits pro-inflammatory mediators through expression of anti-inflammatory HO-1 via ERK pathway.
Selective inhibitory effects of machilin A isolated from Machilus thunbergii on human cytochrome P450 1A and 2B6.
This was the first investigation of the inhibitory effects of MA on CYP1A2 and CYP2B6 in HLMs, and it has identified that MA acts via competitive inhibition.
Bioactive secondary metabolites from an endophytic fungus Phoma sp. PF2 derived from Artemisia princeps Pamp.
Two new isochromanone derivatives and six known compounds isolated from thecultures of an endophytic fungus showed moderate inhibitory activities on nitric oxide levels in lipopolysaccharide-induced RAW264.7 machrophage cells.
Correction to: Anti-inflammatory activity of caffeic acid derivatives isolated from the roots of Salvia miltiorrhiza Bunge
The author would like to include conflict of interest statement of the online published article in order to clarify the statement made by the authors.