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Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008.
OBJECTIVE To estimate the prevalence of gout and hyperuricemia based on the latest nationally representative sample of US men and women (National Health and Nutrition Examination Survey [NHANES]Expand
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Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate GeneticsExpand
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Risk of cardiovascular mortality in patients with rheumatoid arthritis: a meta-analysis of observational studies.
OBJECTIVE To determine the magnitude of risk of cardiovascular mortality in patients with rheumatoid arthritis (RA) compared with the general population through a meta-analysis of observationalExpand
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Genetics of rheumatoid arthritis contributes to biology and drug discovery
A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated variants with diverse genomic and biological data sets to provide insight into diseaseExpand
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Pathogenesis of Gout
Clinical Principles The overall disease burden of gout is substantial and may be increasing. As more scientific data on the modifiable risk factors and comorbidities of gout become available,Expand
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Methotrexate and mortality in patients with rheumatoid arthritis: a prospective study
BACKGROUND Methotrexate is the most frequent choice of disease-modifying antirheumatic therapy for rheumatoid arthritis. Although results of studies have shown the efficacy of such drugs, includingExpand
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Purine-rich foods, dairy and protein intake, and the risk of gout in men.
BACKGROUND Various purine-rich foods and high protein intake have long been thought to be risk factors for gout. Similarly, the possibility that the consumption of dairy products has a role inExpand
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Intake of purine-rich foods, protein, and dairy products and relationship to serum levels of uric acid: the Third National Health and Nutrition Examination Survey.
OBJECTIVE Various commonly consumed foods have long been suspected of affecting the serum uric acid level, but few data are available to support or refute this impression. Our objective was toExpand
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Hyperuricemia and coronary heart disease: A systematic review and meta‐analysis
The role of serum uric acid as an independent risk factor for cardiovascular disease remains unclear, although hyperuricemia is associated with cardiovascular disease such as coronary heart diseaseExpand
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Serum Concentrations of Uric Acid and the Metabolic Syndrome Among US Children and Adolescents
Background— The association between concentrations of uric acid and the metabolic syndrome in children and adolescents remains incompletely understood. The objective of this study was to examine howExpand
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