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Alterations of sucrose preference after Roux-en-Y gastric bypass
Roux-en-Y gastric bypass (gastric bypass) patients reportedly have changes in perception and consumption of sweet-tasting foods. This study aimed to further investigate alterations in sweet foodExpand
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Protection against LPS-induced pulmonary edema through the attenuation of protein tyrosine phosphatase-1B oxidation.
One hallmark of acute lung injury is the disruption of the pulmonary endothelial barrier. Such disruption correlates with increased endothelial permeability, partly through the disruption ofExpand
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Experimental type II diabetes and related models of impaired glucose metabolism differentially regulate glucose transporters at the proximal tubule brush border membrane
What is the central question of this study? Although SGLT2 inhibitors represent a promising treatment for patients suffering from diabetic nephropathy, the influence of metabolic disruption on theExpand
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On the mechanism of sequence-specific DNA-dependent acetylation of p53: the acetylation motif is exposed upon DNA binding.
P53 acetylation requires p300-docking to two contiguous sites in the activation domain that in turn mediates DNA-dependent acetylation of the tetramer. In an attempt to further define the mechanismExpand
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PKC δ and βII regulate angiotensin II-mediated fibrosis through p38: a mechanism of RV fibrosis in pulmonary hypertension.
Pulmonary hypertension (PH) eventually leads to right ventricular (RV) fibrosis and dysfunction that is associated with increased morbidity and mortality. Although angiotensin II plays an importantExpand
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Genetic disruption of protein kinase Cδ reduces endotoxin-induced lung injury.
The pathogenesis of acute lung injury and acute respiratory distress syndrome is characterized by sequestration of leukocytes in lung tissue, disruption of capillary integrity, and pulmonary edema.Expand
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SH2 domain-containing protein tyrosine phosphatase 2 and focal adhesion kinase protein interactions regulate pulmonary endothelium barrier function.
Enhanced protein tyrosine phosphorylation is associated with changes in vascular permeability through formation and dissolution of adherens junctions and regulation of stress fiber formation.Expand
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Select Rab GTPases Regulate the Pulmonary Endothelium via Endosomal Trafficking of Vascular Endothelial-Cadherin.
Pulmonary edema occurs in settings of acute lung injury, in diseases, such as pneumonia, and in acute respiratory distress syndrome. The lung interendothelial junctions are maintained in part byExpand
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Regulation of renal brush-border glucose transport in response to metabolic dysregulation
Diabetic nephropathy is a consequence of hyperglycaemia-induced renal cell damage and a major contributor to end-stage renal disease in later stages of diabetes. Previous studies, in type I diabetes,Expand
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p18, a novel adaptor protein, regulates pulmonary endothelial barrier function via enhanced endocytic recycling of VE‐cadherin
Vascular permeability is a hallmark of several disease states including acute lung injury (ALI). Endocytosis of VE‐cadherin, away from the interendothelial junction (IEJ), causes acute endothelialExpand
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