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Integrative Clinical Genomics of Advanced Prostate Cancer
Toward development of a precision medicine framework for metastatic, castration-resistant prostate cancer (mCRPC), we established a multi-institutional clinical sequencing infrastructure to conductExpand
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MicroRNA profiling: approaches and considerations
MicroRNAs (miRNAs) are small RNAs that post-transcriptionally regulate the expression of thousands of genes in a broad range of organisms in both normal physiological contexts and in diseaseExpand
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Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.
BACKGROUND Inherited mutations in DNA-repair genes such as BRCA2 are associated with increased risks of lethal prostate cancer. Although the prevalence of germline mutations in DNA-repair genes amongExpand
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Quantitative and stoichiometric analysis of the microRNA content of exosomes
Significance Exosomes have been a subject of great interest in recent years, especially in the context of the microRNAs (miRNAs) that they contain. Exosome-mediated miRNA transfer between cells hasExpand
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Circulating microRNA Profiling Identifies a Subset of Metastatic Prostate Cancer Patients with Evidence of Cancer-Associated Hypoxia
MicroRNAs (miRNAs) are small (∼22 nucleotide) non-coding RNAs that regulate a myriad of biological processes and are frequently dysregulated in cancer. Cancer-associated microRNAs have been detectedExpand
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Plasma Processing Conditions Substantially Influence Circulating microRNA Biomarker Levels
Circulating, cell-free microRNAs (miRNAs) are promising candidate biomarkers, but optimal conditions for processing blood specimens for miRNA measurement remain to be established. Our previous workExpand
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Fetal gastro-intestinal and abdominal wall defects: associated malformations and chromosomal abnormalities.
During an 8-year period (1983-1991), blood karyotyping was performed in 235 fetuses with abdominal wall or gastro-intestinal tract defects. The overall incidence of chromosomal abnormalities was 29%Expand
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Integrative Clinical Genomics of Advanced Prostate Cancer
Dan Robinson, Eliezer M. Van Allen, Yi-Mi Wu, Nikolaus Schultz, Robert J. Lonigro, Juan-Miguel Mosquera, Bruce Montgomery, Mary-Ellen Taplin, Colin C. Pritchard, Gerhardt Attard, Himisha Beltran,Expand
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Variations of Nitrogen-15 Abundance in Soils
A survey of the isotopic composition of soil nitrogen has shown that there is variation in the abundance of nitrogen-15 in soils and in different forms of soil nitrogen. The variation detected isExpand
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Mismatch repair deficiency may be common in ductal adenocarcinoma of the prostate
Precision oncology entails making treatment decisions based on a tumor's molecular characteristics. For prostate cancer, identifying clinically relevant molecular subgroups is challenging, asExpand
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