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Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle.
TLDR
The calcium spark is the consequence of elementary events underlying excitation-contraction coupling and provides an explanation for both spontaneous and triggered changes in the intracellular calcium concentration in the mammalian heart. Expand
Relaxation of Arterial Smooth Muscle by Calcium Sparks
TLDR
KCa channels activated by Ca2+ sparks appeared to hyperpolarize and dilate pressurized myogenic arteries because ryanodine and thapsigargin depolarized and constricted these arteries to an extent similar to that produced by blockers of KCa channels. Expand
The control of calcium release in heart muscle.
TLDR
A unifying model for cardiac excitation-contraction coupling is developed that explains the large (but paradoxically stable) amplification of the trigger calcium influx by a combination of digital and analog behavior. Expand
Calcium sparks and [Ca2+]i waves in cardiac myocytes.
TLDR
Ca2+ sparks are elementary events that can explain both the initiation and propagation of Ca2+ waves and electrically evoked Ca2+, and interact with each other in a manner that is consistent with both phenomena having the same underlying mechanism(s). Expand
Amplitude distribution of calcium sparks in confocal images: theory and studies with an automatic detection method.
TLDR
This study developed, implemented, and verified an automated computer algorithm for objective detection and measurement of calcium sparks in raw image data, and observed highly left-skewed or monotonic decreasing amplitude distributions in skeletal muscle cells and cardiomyocytes. Expand
A simple numerical model of calcium spark formation and detection in cardiac myocytes.
TLDR
A parameter sensitivity study reveals that the mobility, kinetics, and concentration of the indicator are essential determinants of the shape of Ca2+ sparks, whereas the stationary buffers and pumps are less influential. Expand
Two mechanisms of quantized calcium release in skeletal muscle
TLDR
A 'dual-control' model for discrete Ca2+ release events from the sacroplasmic reticulum is proposed that unifies diverse observations about Ca2-signalling in frog skeletal muscle, and that may be applicable to other excitable cells. Expand
Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure.
TLDR
The same defect in EC coupling that develops during hypertrophy may contribute to heart failure when compensatory mechanisms fail because it appears to reside in a change in the relation between SR calcium-release channels and sarcolemmal calcium channels. Expand
Direct measurement of SR release flux by tracking ‘Ca2+ spikes’ in rat cardiac myocytes
TLDR
Ca2+ release flux across the sarcoplasmic reticulum (SR) during cardiac excitation‐contraction coupling was investigated using a novel fluorescence method and it appears that not only the amount of Ca2+ released, but also the synchronization among release sites affects the whole‐cell Ca2- transient and the Ca2‐‐myofilament interaction. Expand
Excitation-contraction coupling in heart: new insights from Ca2+ sparks.
TLDR
The current understanding of cardiac excitation-contraction (EC) coupling is examined in light of recent studies on the elementary Ca2+ release events orCa2+ sparks, and Ca2- spark properties in rat and mouse heart cells are characterized. Expand
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