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A High-Resolution Absolute-Dated Late Pleistocene Monsoon Record from Hulu Cave, China
Oxygen isotope records of five stalagmites from Hulu Cave near Nanjing bear a remarkable resemblance to oxygen isotope records from Greenland ice cores, suggesting that East Asian Monsoon intensityExpand
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Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle.
Spontaneous local increases in the concentration of intracellular calcium, called "calcium sparks," were detected in quiescent rat heart cells with a laser scanning confocal microscope and theExpand
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Relaxation of Arterial Smooth Muscle by Calcium Sparks
Local increases in intracellular calcium ion concentration ([Ca2+]i) resulting from activation of the ryanodine-sensitive calcium-release channel in the sarcoplasmic reticulum (SR) of smooth muscleExpand
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Integration of Plant Responses to Environmentally Activated Phytohormonal Signals
Plants live in fixed locations and survive adversity by integrating growth responses to diverse environmental signals. Here, we show that the nuclear-localized growth-repressing DELLA proteins ofExpand
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The control of calcium release in heart muscle.
The control of calcium release from intracellular stores (the sarcoplasmic reticulum) in cardiac muscle was examined with the use of a confocal microscope and voltage clamp techniques. DepolarizationExpand
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Calcium sparks and [Ca2+]i waves in cardiac myocytes.
Local elevations in intracellular calcium ("Ca2+ sparks") in heart muscle are elementary sarcoplasmic reticulum (SR) Ca(2+)-release events. Ca2+ sparks occur at a low rate in quiescent cells but canExpand
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Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure.
Cardiac hypertrophy and heart failure caused by high blood pressure were studied in single myocytes taken from hypertensive rats (Dahl SS/Jr) and SH-HF rats in heart failure. Confocal microscopy andExpand
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Direct measurement of SR release flux by tracking ‘Ca2+ spikes’ in rat cardiac myocytes
1 Ca2+ release flux across the sarcoplasmic reticulum (SR) during cardiac excitation‐contraction coupling was investigated using a novel fluorescence method. Under whole‐cell voltage‐clampExpand
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Direct Determination of the Timing of Sea Level Change During Termination II
An outcrop within the last interglacial terrace on Barbados contains corals that grew during the penultimate deglaciation, or Termination II. We used combined 230Th and231Pa dating to determine thatExpand
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Relation between the sarcolemmal Ca2+ current and Ca2+ sparks and local control theories for cardiac excitation-contraction coupling.
Ca2+ sparks, the elementary events underlying excitation-contraction (E-C) coupling, occur when sarcoplasmic reticulum (SR) Ca2+ release channels open. They are activated locally by Ca2+ influxExpand
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