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Whole-genome amplification: relative efficiencies of the current methods.
Whole genome amplification (WGA) has emerged as a fundamental method for DNA analysis from limited quantities of genomic DNA in forensic analysis and disease gene discovery. Several strategies forExpand
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NMR-detected hydrogen exchange and molecular dynamics simulations provide structural insight into fibril formation of prion protein fragment 106–126
PrP106–126, a peptide corresponding to residues 107–127 of the human prion protein, induces neuronal cell death by apoptosis and causes proliferation and hypertrophy of glia, reproducing the mainExpand
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Immunization with a single extracellular enveloped virus protein produced in bacteria provides partial protection from a lethal orthopoxvirus infection in a natural host.
Subunit vaccines that use the vaccinia virus extracellular envelope protein A33R alone or combined with other structural proteins are excellent candidates for a new smallpox vaccine. Since a newExpand
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Intrinsic disorder and oligomerization of the hepatitis delta virus antigen.
The 195 amino acid basic protein (δAg) of hepatitis delta virus (HDV) is essential for replication of the HDV RNA genome. Numerous properties have been mapped to full-length δAg and attempts made toExpand
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Early events in protein folding explored by rapid mixing methods.
As with any complex reaction, time-resolved data are essential for elucidating the mechanism of protein folding. Even in cases where the whole process of folding occurs in a single step, which is theExpand
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Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons
  • J. Howitt, U. Putz, +8 authors S. Tan
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 8 September 2009
The regulation of metal ion transport within neurons is critical for normal brain function. Of particular importance is the regulation of redox metals such as iron (Fe), where excess levels canExpand
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Rapid mixing methods for exploring the kinetics of protein folding.
Information on the time-dependence of molecular species is critical for elucidating reaction mechanisms in chemistry and biology. Rapid flow experiments involving turbulent mixing of two or moreExpand
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A large novel deletion in the APC promoter region causes gene silencing and leads to classical familial adenomatous polyposis in a Manitoba Mennonite kindred
Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome caused by the inheritance of germline mutations in the APC tumour suppressor gene. The vast majority of these are nonsense andExpand
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Physiological and genomic features of a novel violacein-producing bacterium isolated from surface seawater
Strains JW1T and JW3, isolated from surface seawater of the Arabian Sea, were subjected to polyphasic taxonomic analysis. Cells of both strains were Gram-stain-negative, aerobic, and rod-shaped. TheyExpand
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Solution structure and dynamics of a de novo designed three-helix bundle protein.
Although de novo protein design is an important endeavor with implications for understanding protein folding, until now, structures have been determined for only a few 25- to 30-residue designedExpand
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