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Near Wall Flow over Urban-like Roughness
In this study, comprehensive measurements over a number of urban-type surfaces with the same area density of 25% have been performed in a wind tunnel. The experiments were conducted at a free streamExpand
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Turbulence Over Urban-type Roughness: Deductions from Wind-tunnel Measurements
Turbulence data from experiments conducted over a staggered cube array, modelling a neutrally stable atmospheric boundary layer in an urban environment, are presented. The results support theExpand
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Near-Wall Flow Development After A Step Change In Surface Roughness
An experimental study of the initial flow field downstream of a step change in surface roughness is presented. The roughness length of the downstream surface was approximately tenfold that of theExpand
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Selective Inhibition of Mutant Isocitrate Dehydrogenase 1 (IDH1) via Disruption of a Metal Binding Network by an Allosteric Small Molecule
Background: Mutant-selective IDH1 inhibitors are potential cancer therapeutics, but the mechanistic basis for their selectivity is not yet well understood. Results: Inhibitor binding modes andExpand
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Arginyltransferase ATE1 catalyzes midchain arginylation of proteins at side chain carboxylates in vivo.
Arginylation is an emerging posttranslational modification mediated by Arg-tRNA-protein-transferase (ATE1). It is believed that ATE1 links Arg solely to the N terminus of proteins, requiring priorExpand
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Autoinhibitory interactions between the PDZ2 and C-terminal domains in the scaffolding protein NHERF1.
Na(+)/H(+) exchanger regulatory factor (NHERF1) is a signaling adaptor protein comprising two PDZ domains and a C-terminal ezrin-binding (EB) motif. To understand the role of intramolecularExpand
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Dispersion experiments in central London: the 2007 DAPPLE project.
In the event of a release of toxic gas in the center of London, emergency services personnel would need to determine quickly the extent of the area contaminated. The transport of pollutants byExpand
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Detrital zircon U–Pb dating of low-grade metamorphic rocks in the Sulu UHP belt: evidence for overthrusting of the North China Craton onto the South China Craton during continental subduction
The Shiqiao–Pingshang low-grade metasedimentary rocks sporadically crop out in the Sulu ultrahigh-pressure (UHP) belt in east–central China. Major and trace element data indicate that they wereExpand
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Deformation and diffusion behaviour in a solid experiencing damage: a continuous damage model and its numerical implementation
Abstract A phenomenological damage model is presented for a solid experiencing damage under deformation and pressure diffusion processes. The proposed model is developed using irreversibleExpand
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4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6.
Identification and structure-guided optimization of a series of 4-(pyrazol-4-yl)-pyrimidines as selective CDK4/6 inhibitors is reported herein. Several potency and selectivity determinants wereExpand
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