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The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
TLDR
The TREM2-APOE pathway is identified as a major regulator of microglial functional phenotype in neurodegenerative diseases and serves as a novel target that could aid in the restoration of homeostatic microglia. Expand
Mental health problems and social media exposure during COVID-19 outbreak
TLDR
There are high prevalence of mental health problems, which positively associated with frequently SME during the COVID-19 outbreak, and the government need pay more attention to mental health issues among general population and combating with “infodemic” while combating during public health emergency. Expand
Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles.
The use of single chemotherapeutic drug has shown some limitations in anti-tumor treatment, such as development of drug resistance, high toxicity and limited regime of clinical uses. The combinationExpand
Context-dependent signaling defines roles of BMP9 and BMP10 in embryonic and postnatal development
TLDR
Surprisingly, analysis of Bmp109/9 mice demonstrated that BMP10 has an exclusive function in cardiac development, which cannot be substituted by BMP9, and reveals context-dependent significance in having multiple ligands in a signaling pathway. Expand
miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis.
TLDR
MSCIPFP-derived exosomes protect articular cartilage from damage and ameliorate gait abnormality in OA mice by maintaining cartilage homeostasis, the mechanism of which may be related to miR100-5p-regulated inhibition of mTOR-autophagy pathway. Expand
Invasion of Oral and Aortic Tissues by Oral Spirochete Treponema denticola in ApoE−/− Mice Causally Links Periodontal Disease and Atherosclerosis
TLDR
A causal link for active oral T. denticola periodontal infection and vascular atherosclerosis in vivo in hyperlipidemic ApoE−/− mice is confirmed. Expand
Britanin Ameliorates Cerebral Ischemia-Reperfusion Injury by Inducing the Nrf2 Protective Pathway.
TLDR
The results demonstrate that the natural product Britanin with potent Nrf2-activating and neural protective activities both in vitro and in vivo could be developed into a cerebroprotective therapeutic agent. Expand
Thymosin alpha1- and ulinastatin-based immunomodulatory strategy for sepsis arising from intra-abdominal infection due to carbapenem-resistant bacteria.
TLDR
Immunomodulatory therapy that combines thymosin alpha(1) and ulinastatin appears to improve the survival rate for patients infected with carbapenem-resistant bacteria. Expand
Discovery of Potent Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme UbcH5c from α-Santonin Derivatives.
TLDR
Mechanistic investigations revealed that compound 6d preferentially bound to and inactivated UbcH5c by forming a covalent adduct with its active site Cys85, and exhibited potent anti-inflammatory activity against complete Freund's adjuvant-induced adjUvant arthritis in vivo. Expand
STK31 maintains the undifferentiated state of colon cancer cells.
TLDR
It is reported that STK31 is robustly and heterogeneously expressed in colon cancer tissues and plays a critical role in determining the differentiation state of colon cancer cells. Expand
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