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The RNA Binding Protein hnRNP Q Modulates the Utilization of Exon 7 in the Survival Motor Neuron 2 (SMN2) Gene
ABSTRACT Spinal muscular atrophy (SMA) is a recessive neuromuscular disorder caused by the homozygous loss of the SMN1 gene. The human SMN2 gene has a C-to-T transition at position +6 of exon 7 andExpand
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hnRNP Q Regulates Cdc42-Mediated Neuronal Morphogenesis
ABSTRACT The RNA-binding protein hnRNP Q has been implicated in neuronal mRNA metabolism. Here, we show that knockdown of hnRNP Q increased neurite complexity in cultured rat cortical neurons andExpand
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CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing.
Due to the strong sequence homology it has been suggested that CDC2L5 and CDK12 belong to a high molecular weight subfamily of CDC2 family with PITAI/VRE motifs [F. Marques, J.L. Moreau, G.Expand
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Identification and Characterization of the CDK12/Cyclin L1 Complex Involved in Alternative Splicing Regulation
ABSTRACT CrkRS is a Cdc2-related protein kinase that contains an arginine- and serine-rich (SR) domain, a characteristic of the SR protein family of splicing factors, and is proposed to be involvedExpand
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Optimal Channel Search Time for Handoff in the IEEE 802.11 WLANs
tl;dr
We propose a simple analytical model to calculate the search latency and success probability for the handoff in the IEEE 802.11 WLAN. Expand
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Biliary excretion of furosemide glucuronide in rabbits.
Furosemide (F) was administered to rabbits intravenously and intraduodenaly and the biliary excretion was studied. The major metabolite excreted in bile was furosemide glucuronide (FG). F and acylExpand
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Effects of pulmonary air embolism on discharge of slowly adapting pulmonary stretch receptors.
Pulmonary air embolism (PAE) usually causes small-airway collapse. Local transpulmonary pressure (Ptr) is thought to be closely associated with the activity of slowly adapting pulmonary stretchExpand
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Vagal and mediator mechanisms underlying the tachypnea caused by pulmonary air embolism in dogs.
We investigated the vagal and mediator mechanisms underlying the tachypnea caused by pulmonary air embolism (PAE) in anesthetized and spontaneously breathing dogs. PAE was induced by infusion of airExpand
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Mechanisms underlying stimulation of rapidly adapting receptors during pulmonary air embolism in dogs.
We investigated the mechanisms underlying stimulation of rapidly adapting receptors (RARs) during pulmonary air embolism (PAE). Impulses were recorded from RARs in 43 anesthetized, open-chest andExpand
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DDX3 Activates CBC-eIF3-Mediated Translation of uORF-Containing Oncogenic mRNAs to Promote Metastasis in HNSCC.
Mutated or dysregulated DDX3 participates in the progression and metastasis of cancer via its multiple roles in regulating gene expression and cellular signaling. Here, we show that the highExpand
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