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Interacting Transcription Factors from the Three-Amino Acid Loop Extension Superclass Regulate Tuber Formation1
Using the yeast (Saccharomyces cerevisiae) two-hybrid system and a potato (Solanum tuberosum) KNOX protein, designated POTH1, as bait, we have identified seven distinct interacting proteins from aExpand
Nongenetic method for purifying stem cell–derived cardiomyocytes
It is found that a fluorescent dye that labels mitochondria, tetramethylrhodamine methyl ester perchlorate, could be used to selectively mark embryonic and neonatal rat cardiomyocytes, as well as mouse, marmoset and human PSC-derived cardiomers, and that the cells could subsequently be enriched (>99% purity) by fluorescence-activated cell sorting. Expand
Downregulation of gas5 increases pancreatic cancer cell proliferation by regulating CDK6
Overexpression of gas5 in pancreatic cancer cells inhibits cell proliferation, whereas gas5 inhibition induces a significant decrease in G0/G1 phase and an increase in S phase, and it is demonstrated that gas5 negatively regulates CDK6 (cyclin-dependent kinase 6) expression in vitro and in vivo. Expand
PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression.
It is shown that U HRF1's ability to repress its direct target gene expression is dependent on PHD(UHRF1) binding to unmodified H3R2, thereby demonstrating the functional importance of this recognition event and supporting the potential for crosstalk between histone arginine methylation and UHRF 1 function. Expand
Serum levels of soluble programmed death ligand 1 predict treatment response and progression free survival in multiple myeloma
The serum sPD-L1 level is a valuable biomarker for predicting treatment response and an independent prognostic factor for PFS, and PD-1/PD- L1 blockade may be a promising novel immune-based therapeutic strategy in MM. Expand
ALK1 signaling regulates early postnatal lymphatic vessel development.
This study finds that ALK1 signaling regulates the differentiation of lymphatic endothelial cells to influence the lymphatic vascular development and remodeling, and suggests that targetingALK1 pathway might provide additional control of lymphangiogenesis in human diseases. Expand
Splice variant of the SND1 transcription factor is a dominant negative of SND1 members and their regulation in Populus trichocarpa
A stem-differentiating xylem (SDX)-specific alternative SND1 splice variant, PtrSND1-A2IR, that acts as a dominant negative of S ND1 transcriptional network genes in Populus trichocarpa is discovered and may contribute to transcriptional homeostasis to avoid deleterious effects on xylogenesis and plant growth. Expand
Circ-104916 is downregulated in gastric cancer and suppresses migration and invasion of gastric cancer cells
It is demonstrated that the expression of circ-104916 is downregulated in GC tissues and cell lines, indicating that circ- 104916 was involved in the epithelial–mesenchymal transition process and might be a novel potential tumor suppressor and biomarker of GC. Expand
A novel systemic inflammation response index (SIRI) for predicting the survival of patients with pancreatic cancer after chemotherapy
A systemic inflammation response index (SIRI) based on peripheral neutrophil, monocyte, and lymphocyte counts is developed and the ability of the SIRI to predict the survival of patients with pancreatic cancer who received chemotherapy is evaluated. Expand
D-dimer as a predictor of progressive hemorrhagic injury in patients with traumatic brain injury: analysis of 194 cases
The level of plasma D-dimer after TBI can be a useful prognostic factor for PHI and should be considered in the clinical management of patients in combination with neuroimaging and other data. Expand