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CrystFEL: a software suite for snapshot serial crystallography
In order to address the specific needs of the emerging technique of `serial femtosecond crystallography', in which structural information is obtained from small crystals illuminated by an X-rayExpand
High-resolution ab initio three-dimensional x-ray diffraction microscopy.
TLDR
X-ray diffraction imaging with high resolution in all three dimensions is demonstrated, as determined by a quantitative analysis of the reconstructed volume images, and the techniques to be used in atomic-resolution ultrafast imaging at x-ray free-electron laser sources are established. Expand
Femtosecond X-ray protein nanocrystallography
TLDR
This work offers a new approach to structure determination of macromolecules that do not yield crystals of sufficient size for studies using conventional radiation sources or are particularly sensitive to radiation damage, by using pulses briefer than the timescale of most damage processes. Expand
Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography.
TLDR
This work presents a technique for extruding gel-like LCP with embedded membrane protein microcrystals, providing a continuously renewed source of material for serial femtosecond crystallography. Expand
Phase Retrieval with Application to Optical Imaging: A contemporary overview
TLDR
The goal is to describe the current state of the art in this area, identify challenges, and suggest future directions and areas where signal processing methods can have a large impact on optical imaging and on the world of imaging at large. Expand
An assessment of the resolution limitation due to radiation-damage in x-ray diffraction microscopy.
TLDR
The conclusion of this study is that, based on the natural contrast between protein and water and "Rose-criterion" image quality, one should be able to image a frozen-hydrated biological sample using XDM at a resolution of about 10 nm. Expand
Cheetah: software for high-throughput reduction and analysis of serial femtosecond X-ray diffraction data
The emerging technique of serial X-ray diffraction requires new software tools for the efficient analysis of large volumes of data. Event selection early in the analysis pipeline is highlyExpand
X-ray image reconstruction from a diffraction pattern alone
A solution to the inversion problem of scattering would offer aberration-free diffraction-limited three-dimensional images without the resolution and depth-of-field limitations of lens-basedExpand
High-Resolution Protein Structure Determination by Serial Femtosecond Crystallography
TLDR
Serial femtosecond crystallography (SFX) is applied using an x-ray free-electron laser (XFEL) to obtain high-resolution structural information from microcrystals of the well-characterized model protein lysozyme, demonstrating the immediate relevance of SFX for analyzing the structure of the large group of difficult-to-crystallize molecules. Expand
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