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Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research
A summary of factors that influence transmucosal nasal drug delivery, deposition, and their impact on bioavailability is provided, including variations in anatomy and resultant airflow dynamic, vascularisation, status of blood vessels, mode of spray application, gallenic formulation, and amount and method of administration. Expand
Nano spray drying: a novel method for preparing protein nanoparticles for protein therapy.
The Nano Spray Dryer B-90 thus offers a new, simple and alternative approach for the production of protein nanoparticles suited for a variety of drug delivery applications. Expand
Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids.
Findings suggest that documentation of patient's AHR or sputum eosinophils may be useful in guiding the reduction of ICS doses. Expand
In vitro/in vivo comparisons in pulmonary drug delivery.
  • S. Newman, H. Chan
  • Medicine
  • Journal of aerosol medicine and pulmonary drug…
  • 8 March 2008
Correlations exist between APSD data and whole-lung deposition, and agreement between in vitro and in vivo data may be improved by measuring APSD in ways that more closely mimic clinical use, including the use of impactor inlets that simulate the human upper airway anatomy. Expand
Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 1: Grid structure and mouthpiece length.
The performance of a dry powder inhaler can be affected by simple design changes, and CFD, coupled with experimental results, provides a rational basis for understanding the performance difference. Expand
Influence of Air Flow on the Performance of a Dry Powder Inhaler Using Computational and Experimental Analyses
The use of CFD has provided further insight into the effect of air flow on the performance of the Aerolizer® and the approach of using CFD coupled with powder dispersion is readily applicable to other dry powder inhalers to help better understand their performance optimization. Expand
Influence of Humidity on the Electrostatic Charge and Aerosol Performance of Dry Powder Inhaler Carrier based Systems
Investigation of the influence of storage relative humidity (RH) on the aerosolisation efficiency and tribo-electrification of carrier based dry powder inhaler (DPI) formulations using the next generation impactor (NGI) in vitro methodology and the electrostatic low pressureimpactor (ELPI) found that increased storage RH resulted in a reduction in net charge to mass ratio with the greatest reduction at RH >60%. Expand
Production methods for nanodrug particles using the bottom-up approach.
  • H. Chan, P. Kwok
  • Materials Science, Medicine
  • Advanced drug delivery reviews
  • 30 May 2011
This review focuses on bottom-up processes such as precipitation and single droplet evaporation to produce nanoparticles containing largely pure therapeutics for pharmaceutical applications, and a key to the success of yielding stable nanoparticles in these various techniques is to control the particle growth kinetics throughEvaporation rate of the droplets or mixing rate during precipitation. Expand
Pulmonary delivery of therapeutic siRNA
This review focuses on the latest development of pulmonary delivery of siRNA for the treatment of various lung diseases with a focus on the formulation of si RNA for inhalation. Expand
Formation, characterization, and fate of inhaled drug nanoparticles.
Nanoparticles bring many benefits to pulmonary drug delivery applications, especially for systemic delivery and drugs with poor solubility. They have recently been explored in pressurized meteredExpand