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Mitochondrial proteomics analysis of tumorigenic and metastatic breast cancer markers
- Yi-Wen Chen, H. Chou, +11 authors H. Chan
- Biology, Medicine
- Functional & Integrative Genomics
- 19 January 2011
Mitochondria are key organelles in mammary cells responsible for several cellular functions including growth, division, and energy metabolism. In this study, mitochondrial proteins were enriched for… Expand
Noninvasive, Targeted, and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of Parkinson’s Disease
Glial cell line-derived neurotrophic factor (GDNF) supports the growth and survival of dopaminergic neurons. CNS gene delivery currently relies on invasive intracerebral injection to transit the… Expand
Proteomic analysis of proteins responsible for the development of doxorubicin resistance in human uterine cancer cells.
Drug resistance is a common cause of failure in cancer chemotherapy treatments. In this study, we used a pair of uterine sarcoma cancer lines, MES-SA, and the doxorubicin-resistant MES-SA/Dx5 as a… Expand
High glucose-induced proteome alterations in hepatocytes and its possible relevance to diabetic liver disease.
- J. Chen, H. Chou, You-Hsuan Chen, H. Chan
- Chemistry, Medicine
- The Journal of nutritional biochemistry
- 1 November 2013
Hyperglycemia can cause several abnormalities in liver cells, including diabetic liver disease. Previous research has shown that high blood glucose levels can damage liver cells through… Expand
Proteomic analysis of retinopathy-related plasma biomarkers in diabetic patients.
- Chieh-hsiang Lu, Szu-Ting Lin, H. Chou, Ying-Ray Lee, H. Chan
- Archives of biochemistry and biophysics
- 15 January 2013
Diabetic retinopathy occurs in approximately 25% of patients with type 1 or type 2 diabetes; the disease can cause poor vision and even blindness because high glucose levels weaken retinal… Expand
Intrahepatic hepatitis B virus large surface antigen induces hepatocyte hyperploidy via failure of cytokinesis
- Tian-Neng Li, Yi-Ju Wu, +13 authors L. H. Wang
- Biology, Medicine
- The Journal of pathology
- 1 August 2018
Hepatitis B virus (HBV) is an aetiological factor for liver cirrhosis and hepatocellular carcinoma (HCC). Despite current antiviral therapies that successfully reduce the viral load in patients with… Expand
Trypsin-induced proteome alteration during cell subculture in mammalian cells
- Hsiang-Ling Huang, Hsiang-Wei Hsing, +12 authors H. Chan
- Biology, Medicine
- Journal of Biomedical Science
- 11 May 2010
BackgroundIt is essential to subculture the cells once cultured cells reach confluence. For this, trypsin is frequently applied to dissociate adhesive cells from the substratum. However, due to the… Expand
Secretomic and proteomic analysis of potential breast cancer markers by two-dimensional differential gel electrophoresis.
The transformation of a normal cell into a cancer cell has been correlated with alterations in gene regulation and protein expression. To identify altered proteins and link them to the tumorigenesis… Expand
Proteomic analysis of gemcitabine-induced drug resistance in pancreatic cancer cells.
Currently, the most effective agent against pancreatic cancer is gemcitabine (GEM), which inhibits tumor growth by interfering with DNA replication and blocking DNA synthesis. However, GEM-induced… Expand
Cardioprotective Effects of Quercetin in Cardiomyocyte under Ischemia/Reperfusion Injury
- Yi-Wen Chen, H. Chou, +4 authors H. Chan
- Evidence-based complementary and alternative…
- 14 March 2013
Quercetin, a polyphenolic compound existing in many vegetables, fruits, has antiinflammatory, antiproliferation, and antioxidant effect on mammalian cells. Quercetin was evaluated for protecting… Expand