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Mitochondrial proteomics analysis of tumorigenic and metastatic breast cancer markers
  • Yi-Wen Chen, H. Chou, +11 authors H. Chan
  • Biology, Medicine
  • Functional & Integrative Genomics
  • 19 January 2011
Mitochondria are key organelles in mammary cells responsible for several cellular functions including growth, division, and energy metabolism. In this study, mitochondrial proteins were enriched forExpand
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Noninvasive, Targeted, and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of Parkinson’s Disease
Glial cell line-derived neurotrophic factor (GDNF) supports the growth and survival of dopaminergic neurons. CNS gene delivery currently relies on invasive intracerebral injection to transit theExpand
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Proteomic analysis of proteins responsible for the development of doxorubicin resistance in human uterine cancer cells.
Drug resistance is a common cause of failure in cancer chemotherapy treatments. In this study, we used a pair of uterine sarcoma cancer lines, MES-SA, and the doxorubicin-resistant MES-SA/Dx5 as aExpand
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High glucose-induced proteome alterations in hepatocytes and its possible relevance to diabetic liver disease.
Hyperglycemia can cause several abnormalities in liver cells, including diabetic liver disease. Previous research has shown that high blood glucose levels can damage liver cells throughExpand
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Proteomic analysis of retinopathy-related plasma biomarkers in diabetic patients.
Diabetic retinopathy occurs in approximately 25% of patients with type 1 or type 2 diabetes; the disease can cause poor vision and even blindness because high glucose levels weaken retinalExpand
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Intrahepatic hepatitis B virus large surface antigen induces hepatocyte hyperploidy via failure of cytokinesis
Hepatitis B virus (HBV) is an aetiological factor for liver cirrhosis and hepatocellular carcinoma (HCC). Despite current antiviral therapies that successfully reduce the viral load in patients withExpand
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Trypsin-induced proteome alteration during cell subculture in mammalian cells
BackgroundIt is essential to subculture the cells once cultured cells reach confluence. For this, trypsin is frequently applied to dissociate adhesive cells from the substratum. However, due to theExpand
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Secretomic and proteomic analysis of potential breast cancer markers by two-dimensional differential gel electrophoresis.
The transformation of a normal cell into a cancer cell has been correlated with alterations in gene regulation and protein expression. To identify altered proteins and link them to the tumorigenesisExpand
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Proteomic analysis of gemcitabine-induced drug resistance in pancreatic cancer cells.
Currently, the most effective agent against pancreatic cancer is gemcitabine (GEM), which inhibits tumor growth by interfering with DNA replication and blocking DNA synthesis. However, GEM-inducedExpand
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Cardioprotective Effects of Quercetin in Cardiomyocyte under Ischemia/Reperfusion Injury
  • Yi-Wen Chen, H. Chou, +4 authors H. Chan
  • Medicine
  • Evidence-based complementary and alternative…
  • 14 March 2013
Quercetin, a polyphenolic compound existing in many vegetables, fruits, has antiinflammatory, antiproliferation, and antioxidant effect on mammalian cells. Quercetin was evaluated for protectingExpand
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