• Publications
  • Influence
Inhibitory effects of chitooligosaccharides on tumor growth and metastasis.
Chitooligosaccharides (COS) are hydrolyzed products of chitosan and have been proven to exhibit various biological functions. The objectives of this study were to evaluate the anti-tumor growth,Expand
  • 151
  • 4
Probiotics prevent the development of 1,2-dimethylhydrazine (DMH)-induced colonic tumorigenesis through suppressed colonic mucosa cellular proliferation and increased stimulation of macrophages.
Probiotics modulate immunity and inhibit colon carcinogenesis in experimental models, but these effects largely depend on the bacterial strain, and the precise mechanisms are not well understood.Expand
  • 43
  • 2
Secondary metabolites produced by an endophytic fungus Cordyceps ninchukispora from the seeds of Beilschmiedia erythrophloia Hayata
Abstract Four new amide derivatives, designated as cordycepiamides A–D (1–4), together with 14 known compounds (5–18), were isolated from the EtOAc-soluble fraction of the 95% EtOH extract ofExpand
  • 4
  • 2
Composite chondroitin-6-sulfate/dermatan sulfate/chitosan scaffolds for cartilage tissue engineering.
Conjugating a single glycosaminoglycan (GAG) species such as chondroitin-6-sulfate (CSC) to chitosan is beneficial to chondrocyte culture and extracellular matrix (ECM) production, but whetherExpand
  • 104
  • 1
Co‐conjugating chondroitin‐6‐sulfate/dermatan sulfate to chitosan scaffold alters chondrocyte gene expression and signaling profiles
Co‐conjugating chondroitin‐6‐sulfate (CSC) and dermatan sulfate (DS) to chitosan scaffolds improves chondrocyte differentiation and extracellular matrix (ECM) production. To further elucidate theExpand
  • 23
  • 1
Rational development of GAG-augmented chitosan membranes by fractional factorial design methodology.
To develop a novel biomaterial for chondrocyte culture, 8 glycosaminoglycan (GAG)/chitosan membranes (groups N1-N8) were prepared, with the aid of a 2-level 2(4-1) fractional factorial design, byExpand
  • 34
  • 1
New Metabolites from the Endophytic Fungus Mollisia sp.
Two new metabolites, mollisinols A and B (1 and 2), and one first isolated from nature, mollisilactone (3), along with 13 known compounds (4–16), were isolated from the EtOAc-soluble fraction of theExpand
  • 2
  • 1
Chitosan prevents the development of AOM‐induced aberrant crypt foci in mice and suppressed the proliferation of AGS cells by inhibiting DNA synthesis
We study the effect of fungal‐derived chitosan on the development of chemical‐induced colonic precancerous lesions in ICR mice and delineate its possible molecular mechanisms. In the 2 weeksExpand
  • 25
New Chemical Constituents from the Endophytic Fungus Xylariapapulis Cultivated on Taiwanese Lepidagathisstenophylla
The endophytic strain Xylaria papulis was originated from the stem of Taiwanese Lepidagathis stenophylla C. B. Clarke ex Hayata (Acanthaceae) growing in the Hengchun Peninsula of southern Taiwan.Expand
  • 8
  • PDF
A New Pyrrole Metabolite from the Endophytic Fungus of Xylaria papulis
One new pyrrole derivative, papupyrrolal (1), together with seven known metabolites consisting of three flavonoids [myricitrin (2), quercitrin (3), and myricetin (4)], and four triterpenoidsExpand
  • 5