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Neurohumoral features of myocardial stunning due to sudden emotional stress.
TLDR
Emotional stress can precipitate severe, reversible left ventricular dysfunction in patients without coronary disease andaggerated sympathetic stimulation is probably central to the cause of this syndrome. Expand
Tricuspid annular displacement predicts survival in pulmonary hypertension.
TLDR
TAPSE powerfully reflects RV function and prognosis in PAH and persisted after adjusting for other echocardiographic and hemodynamic variables and baseline treatment status. Expand
Pulmonary hypertension due to left heart diseases.
TLDR
Although there is no validated treatment for PH-LHD, insights into management are provided and recommendations for future clinical trials to establish safety and efficacy of novel compounds to target this area of unmet medical need are provided. Expand
Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary hypertension.
TLDR
Doppler echocardiography may frequently be inaccurate in estimating pulmonary artery pressure and cardiac output in patients being evaluated for PH, according to a prospective study on patients with various forms of PH. Expand
Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
TLDR
It is shown that blocking the intrinsic catabolism of cGMP with an oral phosphodiesterase-5A (PDE5A) inhibitor (sildenafil) suppresses chamber and myocyte hypertrophy, and improves in vivo heart function in mice exposed to chronic pressure overload induced by transverse aortic constriction. Expand
[Pulmonary hypertension in chronic lung diseases].
TLDR
The "severe PH group" includes only a minority of chronic lung disease patients who are suspected of having strong general vascular abnormalities accompanying the parenchymal disease and with evidence of an exhausted circulatory reserve rather than an exhausted ventilatory reserve underlying the limitation of exercise capacity. Expand
Diagnosis and assessment of pulmonary arterial hypertension.
TLDR
A clear definition of pulmonary hypertension and the development of a rational approach to diagnostic assessment and follow-up using both conventional and new tools will be essential to deriving maximal benefit from the expanding therapeutic armamentarium. Expand
Arginase Reciprocally Regulates Nitric Oxide Synthase Activity and Contributes to Endothelial Dysfunction in Aging Blood Vessels
TLDR
These findings demonstrate that arginase modulates NOS activity, likely by regulating intracellular l-arginine availability, and may therefore be a therapeutic target. Expand
Comprehensive invasive and noninvasive approach to the right ventricle-pulmonary circulation unit: state of the art and clinical and research implications.
TLDR
The degree of pulmonary hypertension (ie, PA pressure [PAP]) does not strongly correlate with symptoms or survival, whereas RV mass and size and right atrial pressure reflect functional status and are strong predictors of survival. Expand
Clinical differences between idiopathic and scleroderma-related pulmonary hypertension.
TLDR
There are significant clinical and survival differences between IPAH and PAH-Scl, and the presence of left heart disease, although more common in PAH, was not predictive of the higher mortality in these patients. Expand
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