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Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2
A “two-hit” stress model in mice is established wherein stress at a specific postnatal period increases susceptibility to adult social defeat stress and causes long-lasting transcriptional alterations that prime the ventral tegmental area (VTA)—a brain reward region—to be in a depression-like state.
Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility
Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors
The mechanism linking chromatin dynamics to neurobiological phenomena is investigated by applying engineered transcription factors to selectively modify chromatin at a specific mouse gene in vivo and it is found that histone methylation or acetylation at the Fosb locus in nucleus accumbens, a brain reward region, was sufficient to control drug- and stress-evoked transcriptional and behavioral responses.
Cocaine Self-administration Alters Transcriptome-wide Responses in the Brain’s Reward Circuitry
Incubation of Methamphetamine Craving Is Associated with Selective Increases in Expression of Bdnf and Trkb, Glutamate Receptors, and Epigenetic Enzymes in Cue-Activated Fos-Expressing Dorsal…
Results demonstrate a critical role of DS in incubation of methamphetamine craving and that this incubation is associated with selective gene-expression alterations in cue-activated D1- and D2-expressing DS neurons.
MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes
Small RNA-sequencing in paired samples from MDD patients enrolled in a large, randomized placebo-controlled trial of duloxetine collected before and 8 weeks after treatment revealed differential expression of microRNAs according to treatment response, indicating that these miRNAs are consistent markers of treatment response and regulators of the MAPK/Wnt systems.
Ketamine and Imipramine Reverse Transcriptional Signatures of Susceptibility and Induce Resilience-Specific Gene Expression Profiles
ACF chromatin remodeling complex mediates stress–induced depressive–like behavior
It is established that persistent upregulation of the ACF (ATP-utilizing chromatin assembly and remodeling factor) ATP-dependent chromatin-remodeling complex, occurring in the nucleus accumbens of stress-susceptible mice and depressed humans, is necessary for stress-induced depressive-like behaviors.
Integrative Analysis of Sex-Specific microRNA Networks Following Stress in Mouse Nucleus Accumbens
It is found that males and females mount fundamentally different transcriptional and post-transcriptional responses to SCVS and engage sex-specific molecular processes following stress, which have implications for the pathophysiology and treatment of stress-related disorders in women.