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Histone deacetylases (HDACs): characterization of the classical HDAC family.
- Annemieke J M de Ruijter, A. V. Van Gennip, H. Caron, S. Kemp, A. V. van Kuilenburg
- Biology, Medicine
- The Biochemical journal
- 15 March 2003
The aim of this review is to give a comprehensive overview of the structure, function and tissue distribution of members of the classical histone deacetylase (HDAC) family, in order to gain insight into the regulation of gene expression through HDAC activity. Expand
Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes
The genomic landscape of neuroblastoma reveals two novel molecular defects, chromothripsis and neuritogenesis gene alterations, which frequently occur in high-risk tumours. Expand
Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features
The new medulloblastoma classification presented in this study will greatly enhance the understanding of this heterogeneous disease and enable a better selection and evaluation of patients in clinical trials, and it will support the development of new molecular targeted therapies. Expand
Neuroblastoma: biology, prognosis, and treatment.
- Julie R. Park, A. Eggert, H. Caron
- Medicine, Biology
- Hematology/oncology clinics of North America
- 1 February 2010
This article summarizes the understanding of neuroblastoma biology and prognostic features and discusses their impact on current and proposed risk stratification schemas, risk-based therapeutic approaches, and the development of novel therapies for patients at high risk for failure. Expand
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression
- J. Molenaar, R. Domingo-Fernández, +27 authors J. Schulte
- Biology, Medicine
- Nature Genetics
- 1 November 2012
It is reported that LIN28B showed genomic aberrations and extensive overexpression in high-risk neuroblastoma compared to several other tumor entities and normal tissues and was an independent risk factor for adverse outcome in neuroblastomas. Expand
Medical assessment of adverse health outcomes in long-term survivors of childhood cancer.
In young adulthood, a substantial proportion of childhood cancer survivors already has a high or severe burden of disease, particularly after radiotherapy, which underscores the need for lifelong risk-stratified medical surveillance of Childhood cancer survivors. Expand
The Human Transcriptome Map: Clustering of Highly Expressed Genes in Chromosomal Domains
The resulting Human Transcriptome Map generates gene expression profiles for any chromosomal region in 12 normal and pathologic tissue types and provides a tool to search for genes that are overexpressed or silenced in cancer. Expand
N‐myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis
Data suggest that N‐myc genes function as major regulators of the protein synthesis machinery in neuroblastomas. Expand
The human transcriptome map reveals extremes in gene density, intron length, GC content, and repeat pattern for domains of highly and weakly expressed genes.
- R. Versteeg, B. V. van Schaik, +5 authors A. V. van Kampen
- Biology, Medicine
- Genome research
- 1 September 2003
Ridges are found to be very gene-dense domains with a high GC content, a high SINE repeat density, and a low LINE repeat density and are an integral part of a higher order structure in the genome related to transcriptional regulation. Expand
Coping and family functioning predict longitudinal psychological adaptation of siblings of childhood cancer patients.
- B. Houtzager, F. Oort, J. Hoekstra-Weebers, H. Caron, M. Grootenhuis, B. Last
- Psychology, Medicine
- Journal of pediatric psychology
- 1 December 2004
Siblings of pediatric cancer patients are most affected by the illness in the first months and children at risk may be identified according to sibling age and gender and according to long-term family adaptation processes and sibling coping abilities. Expand