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Molecular and Cellular Mechanisms of Ecstasy-Induced Neurotoxicity: An Overview
TLDR
The main aim of this review was to contribute to the understanding of the cellular and molecular mechanisms involved in MDMA neurotoxicity, which can help in the development of therapeutic approaches to prevent or treat the long-term neuropsychiatric complications of MDMA abuse in humans. Expand
Toxicity of amphetamines: an update
TLDR
The long-studied classical amphetamines—amphetamine itself, as well as methamphetamine and MDMA provide plenty of data that may be useful to predict toxicological outcome to improvident abusers and are for that reason the main focus of this review. Expand
Paraquat exposure as an etiological factor of Parkinson's disease.
TLDR
PQ-induced lipid peroxidation and consequent cell death of dopaminergic neurons can be responsible for the onset of the Parkinsonian syndrome, thus indicating that this herbicide may induce PD or influence its natural course. Expand
Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy.
TLDR
In this review, a new focus is brought on the therapeutic interest of inducing and/or activating P-gp for limiting the toxicity caused by its substrates, and several in vivo and in vitro studies validating the use of such a therapeutic strategy are discussed. Expand
Piperazine compounds as drugs of abuse.
TLDR
Toxicokinetic properties, including metabolic pathways, actions and effects in animals and humans, with some hypothesis of mechanism of action, and analytical approaches for the identification of these drugs are summarized in this review. Expand
GC determination of acetone, acetaldehyde, ethanol, and methanol in biological matrices and cell culture.
TLDR
A gas chromatography with flame ionization detection method with direct injection, using a capillary column, was validated to determine ethanol, acetaldehyde, methanol, and acetone in different human matrices with clinical and forensic interest, making it suitable for the routine of clinical biochemistry and forensic laboratories. Expand
Combination effects of amphetamines under hyperthermia ‐ the role played by oxidative stress
TLDR
It is indicated that amphetamine mixtures produce deleterious effects, even when individual drugs are combined at negligible concentrations, and these effects are strongly exacerbated in hyperthermia, emphasizing the potential increased risks of ecstasy intake, especially whenhyperthermia occurs concurrently with polydrug abuse. Expand
Toxicogenomics directory of chemically exposed human hepatocytes
TLDR
The introduced toxicotranscriptomics directory offers a basis for a rationale choice of candidate genes for biomarker evaluation studies and represents an easy to use source of background information on chemically influenced genes. Expand
In vitro neurotoxicity evaluation of piperazine designer drugs in differentiated human neuroblastoma SH‐SY5Y cells
TLDR
Overall, piperazine designer drugs are potentially neurotoxic, supporting concerns on risks associated with the abuse of these drugs. Expand
Cellular Models and In Vitro Assays for the Screening of modulators of P-gp, MRP1 and BCRP
TLDR
This article provides a review of the available cellular models, in vitro and ex vivo assays for the screening and selection of safe and specific inducers and activators of these membrane transporters involved in multidrug resistance expressed in tissues of toxicological relevance. Expand
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