H. Canton

Publications8
h-index5
Citations224
Highly Influential Citations17
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Agonist Properties of N,N-Dimethyltryptamine at Serotonin 5-HT2A and 5-HT2C Receptors
Extensive behavioral and biochemical evidence suggests an agonist role at the 5-HT2A receptor, and perhaps the 5-HT2C receptor, in the mechanism of action of hallucinogenic drugs. However the… Expand
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Competitive antagonism of serotonin (5-HT)2C and 5-HT2A receptormediated phosphoinositide (PI) turnover by clozapine in the rat: A comparison to other antipsychotics
The antagonist actions of clozapine and several other antipsychotics at 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors were studied using the in vitro model of 5-HT-induced phosphoinositide (PI)… Expand
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Identification of rat serotonin 5-HT2C receptors as glycoproteins containing N-linked oligosaccharides.
Antibodies against a portion of the rat 5-HT2C receptor third intracellular loop were generated and used to identify receptors solubilized from cell lines and rat brain. Western blots of… Expand
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Characterization of Potent and Selective Antagonists at Postsynaptic 5- HT1A Receptors in a Series of N4-Substituted Arylpiperazines.
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Glutamate and glycine co-activate while polyamines merely modulate the NMDA receptor complex
1. Agonists may act at any one of three sites on the N-methyl-D-aspartate (NMDA) receptor-effector complex to promote opening of the associated ion channel. The three sites are activated by i) NMDA,… Expand
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Developmental switch in the hippocampal serotonin receptor linked to phosphoinositide hydrolysis
5-HT2A and 5-HT2C receptors couple to the phosphoinositide hydrolysis signal transduction pathway. The present pharmacological analyses provide evidence for a switch in the functional 5-HT receptor… Expand
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P-4-12 In vitro and ex vivo patterns of occupation of 5-HT2A and α1-adrenergic as compared to dopamine D2 receptors by novel antipsychotics
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BENZODIOXEPIPERAZINE DERIVATIVES AS NOVEL 5-HT1A ANTAGONISTS: A PHARMACOLOGICAL EVALUATION OF THEIR SELECTIVITY AND PURITY