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Agonist Properties of N,N-Dimethyltryptamine at Serotonin 5-HT2A and 5-HT2C Receptors
- R. Smith, H. Canton, R. Barrett, E. sanders-Bush
- Chemistry, Medicine
- Pharmacology Biochemistry and Behavior
- 1 November 1998
Extensive behavioral and biochemical evidence suggests an agonist role at the 5-HT2A receptor, and perhaps the 5-HT2C receptor, in the mechanism of action of hallucinogenic drugs. However the… Expand
Competitive antagonism of serotonin (5-HT)2C and 5-HT2A receptormediated phosphoinositide (PI) turnover by clozapine in the rat: A comparison to other antipsychotics
The antagonist actions of clozapine and several other antipsychotics at 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors were studied using the in vitro model of 5-HT-induced phosphoinositide (PI)… Expand
Identification of rat serotonin 5-HT2C receptors as glycoproteins containing N-linked oligosaccharides.
- J. R. Backstrom, R. Westphal, H. Canton, E. sanders-Bush
- Biology, Medicine
- Brain research. Molecular brain research
- 1 November 1995
Antibodies against a portion of the rat 5-HT2C receptor third intracellular loop were generated and used to identify receptors solubilized from cell lines and rat brain. Western blots of… Expand
Characterization of Potent and Selective Antagonists at Postsynaptic 5- HT1A Receptors in a Series of N4-Substituted Arylpiperazines.
Glutamate and glycine co-activate while polyamines merely modulate the NMDA receptor complex
1. Agonists may act at any one of three sites on the N-methyl-D-aspartate (NMDA) receptor-effector complex to promote opening of the associated ion channel. The three sites are activated by i) NMDA,… Expand
Developmental switch in the hippocampal serotonin receptor linked to phosphoinositide hydrolysis
5-HT2A and 5-HT2C receptors couple to the phosphoinositide hydrolysis signal transduction pathway. The present pharmacological analyses provide evidence for a switch in the functional 5-HT receptor… Expand
P-4-12 In vitro and ex vivo patterns of occupation of 5-HT2A and α1-adrenergic as compared to dopamine D2 receptors by novel antipsychotics