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Survivin 2α: a novel Survivin splice variant expressed in human malignancies
TLDR
It is hypothesized that survivin 2α can alter the anti-apoptotic functions of survivin in malignant cells, and may be useful as a therapeutic tool in sensitizing chemoresistant tumor cells to chemotherapy. Expand
Survivin splice variants regulate the balance between proliferation and cell death
TLDR
It is shown that the diverse functional roles of survivin can be explained, in part, by its heterodimerization with survivin splice variants in tumor cells, which is likely to have a significant impact in the design of biologic agents for clinical therapy. Expand
Essential Role for Survivin in Early Brain Development
TLDR
This study is the first to solidify a role for survivin as an antiapoptotic protein during normal neuronal development in vivo, and may impact on the understanding of neural repair, neural development, and neurodegenerative diseases. Expand
NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets.
TLDR
It is demonstrated that trafficking through the Golgi is necessary for ER membrane localization of the protein and a model for the association of NSDHL with lipid droplets is proposed, which may provide another mechanism for regulation of the levels of accumulation of intracellular cholesterol. Expand
Survivin-directed RNA interference cocktail is a potent suppressor of tumour growth in vivo
TLDR
The findings support a role for Survivin in rhabdomyosarcoma biology and provide preliminary evidence for the therapeutic use of Survivin-targeted RNA interference for human tumours that express high levels of this molecule. Expand
Placental defects are associated with male lethality in bare patches and striated embryos deficient in the NAD(P)H Steroid Dehydrogenase-like (NSDHL) Enzyme.
TLDR
It is hypothesize that abnormalities in cells of the allantoic mesoderm that undergo random X-inactivation and form the endothelial lining of the fetal vessels of the labyrinth are associated with the male lethality, perhaps through disruption of an as yet unidentified signaling pathway. Expand
Dissecting the role of endothelial Survivin ΔEx3 in angiogenesis
TLDR
The data indicate that Survivin ΔEx3 may regulate angiogenesis via several mechanisms including cell invasion, migration, and Rac1 activation, and a novel mechanism for Rac1activation during ang iogenesis. Expand
Survivin, Survivin-2B, and Survivin-deItaEx3 expression in medulloblastoma: biologic markers of tumour morphology and clinical outcome
TLDR
A role for Survivin as a marker of tumour morphology and clinical outcome in medulloblastoma is demonstrated and Survivin may be a promising future prognostic tool and potential biologic target in this malignancy. Expand
Survivin: An inhibitor of apoptosis in pediatric cancer
TLDR
An overview of Survivin function and current research exploring its biologic and therapeutic roles in pediatric tumors is presented. Expand
Survivin and Granzyme B–induced apoptosis, a novel anticancer therapy
TLDR
It is predicted that SAGA will be useful therapeutically in any human cancer that expresses Survivin and Granzyme B, and has the potential to be a potent agent for the treatment of primary and recurrent human ovarian carcinoma. Expand
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