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Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and
  • Leandra Ziad A Zargar Abdul Niveen M Benjamin Cecilia Robe Abarca-Gómez Abdeen Hamid Abu-Rmeileh Acosta-Cazar, Leandra Abarca-Gómez, +1,022 authors M. Ezzati
  • Medicine
  • The Lancet
  • 16 December 2017
TLDR
Trends in mean BMI have recently flattened in northwestern Europe and the high-income English-speaking and Asia-Pacific regions for both sexes, southwestern Europe for boys, and central and Andean Latin America for girls, and by contrast, the rise in BMI has accelerated in east and south Asia forboth sexes, and southeast Asia for boys. Expand
Association analysis identifies 65 new breast cancer risk loci
TLDR
A genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry finds that heritability of Breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2–5-fold enriched relative to the genome- wide average. Expand
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
TLDR
A meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, and identified 29,807 SNPs for further genotyping suggests that more than 1,000 additional loci are involved in breast cancer susceptibility. Expand
Genome-wide association studies identify four ER negative–specific breast cancer risk loci
TLDR
SNPs at four loci were associated with ER-negative but not ER-positive breast cancer (P > 0.05), providing further evidence for distinct etiological pathways associated with invasive ER- positive and ER- negative breast cancers. Expand
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
TLDR
15 new loci associated with breast cancer at P < 5 × 10−8 are identified, and one association appears to be driven by an amino acid substitution encoded in EXO1, which is found in women of European ancestry. Expand
Soy food intake and breast cancer survival.
TLDR
Among women with breast cancer, soy food consumption was significantly associated with decreased risk of death and recurrence, and the inverse association was evident among women with either estrogen receptor-positive or -negative breast cancer. Expand
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
TLDR
Using the Illumina custom genotyping array iCOGs, SNPs at the TERT locus in breast, ovarian and BRCA1 mutation carrier cancer cases and controls and leukocyte telomere measurements are analyzed to find associations cluster into three independent peaks. Expand
Dietary calcium and magnesium intakes and the risk of type 2 diabetes: the Shanghai Women's Health Study.
TLDR
It is suggested that calcium and magnesium intakes may protect against the development of type 2 diabetes in this population of women, and milk intake was inversely associated with the risk of T2D. Expand
Dietary and lifestyle predictors of age at natural menopause and reproductive span in the Shanghai Women's Health Study
TLDR
In addition to reproductive factors, intake of fruits and protein, smoking, tea consumption, lifetime patterns of physical activity, and weight gain influenced the onset of menopause and/or reproductive span in Chinese women. Expand
Association of cyclin D1 genotype with breast cancer risk and survival.
TLDR
It is found that the CCND1 A870G polymorphism was inversely associated with overall and disease-free survival, particularly among women with late stage or estrogen/progesterone receptor-negative breast cancer. Expand
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