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Pharmacology and neurochemistry of buspirone.
TLDR
Buspirone appears to interact only with the dopaminergic system and possesses properties that are similar to both dopamine agonists and dopamine antagonists.
Studies on isoproterenol-induced cardiomegaly in rats.
Effects of anagrelide on platelet cAMP levels, cAMP-dependent protein kinase and thrombin-induced Ca++ fluxes.
TLDR
It is suggested that anagrelide inhibits platelet phosphodiesterase activity in intact platelets resulting in an elevation in cAMP levels sufficient to activate the cAMP-dependent protein kinase and inhibit agonist-activated Ca++ fluxes.
CARDIOVASCULAR PHARMACOLOGY OF TWO NEW β-ADRENERGIC RECEPTOR ANTAGONISTS
TLDR
The β-adrenergic receptor blocking activities of three agents, MJ 1999, but not MJ 1998, partially protected guinea pigs from ouabain cardiotoxicity and reduced the atrial rate of animals with atrial flutter induced by aconitine or injury stimulation.
Adrenergic mechanism responsible for submandibular salivary glandular hypertrophy in the rat.
TLDR
The salivary gland growth induced by sympathomimetic amines, amputation or papain seems to involve, predominantly, stimulation of adrenergic beta receptors.
Effects of a hydrazine monoamine oxidase inhibitor (phenelzine) on isoproterenol-induced myocardiopathies in the rat.
TLDR
Phenetzine partially prevented grossly detectable cardiac necrosis and cardiomegaly induced in the rat by large, multiple doses of isoproterenol and new protein synthesis seems to occur with repeated ISO administration.
Inhibitors of inositol trisphosphate-induced Ca2+ release from isolated platelet membrane vesicles.
TLDR
Of the plasma membrane Ca2+ channel blockers, cinnarizine and flunarizines were found to be potent inhibitors of IP3-induced Ca2-induced release while having no effect on ATP-dependent Ca2+, and may prove useful as probes of the IP2+ release channels.
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